Peripheral Mechanisms of Itch

Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.

Automated summary

The article summarizes the neural pathways of itch sensation and the complex interactions between skin, immune cells, and neurons in detecting itch-inducing irritants. It also highlights recent discoveries related to acute itch detection in the skin.