Interactions of the Neuro-Immune-Stromal Triad in Itch

This review focuses on recent advances in understanding the mechanisms involved in itch signaling in the skin and how these new findings fit into the wider picture of the expression of itch mediators and their receptors in the dermal layer. Because at present studies mostly concentrate on single cellular compartments (e.g., neural alone), we suggest that they may miss important interactions with other compartments. Therefore, to fully appreciate pruritus, we propose that studies should consider (e.g., using transcriptomic information) signal transmission within the entire neuro-immune-stromal triad.

Automated summary

The review highlights recent advances in understanding itch signaling in the skin, suggesting that current studies focusing on single cellular compartments may miss important interactions. To fully appreciate pruritus, the proposal is made for studies to consider signal transmission within the entire neuro-immune-stromal triad using transcriptomic information.