期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 49, 期 12, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/03000605211063721
关键词
Asthma; atorvastatin; eosinophils; periostin; pulmonary function test; spirometry
资金
- Shiraz University of Medical Sciences [15216]
The study results indicated that atorvastatin treatment did not significantly impact lung function and inflammatory markers in patients with asthma, and there were no significant differences between the placebo and intervention groups.
Objective To investigate the effect of atorvastatin on serum periostin level and blood eosinophil count in patients with asthma. Methods Patients diagnosed with asthma were enrolled and randomised into an intervention or placebo group, to receive 40 mg atorvastatin or similar placebo, daily, for 8 weeks. Spirometry was performed at baseline, and at the end of weeks 4 and 8; patients also provided blood samples and completed an asthma control test (ACT) at baseline and at the end of week 8. Primary study outcomes were blood eosinophil count and serum periostin levels. Results Eighty patients completed the study (40 per group). Mean ACT scores were similar between the intervention and placebo groups at baseline (17.95 +/- 3.75 versus 17.98 +/- 3.77, respectively), and improved in the intervention group (19.88 +/- 3.28), but remained unchanged in the placebo group (18.6 +/- 3.26) during the treatment period. No statistically significant differences in spirometric changes, blood eosinophil count or serum periostin levels were observed between the groups during the treatment period. Conclusion Spirometric parameters and inflammatory markers did not change significantly in response to atorvastatin treatment, and did not differ between the placebo and intervention groups.
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