Gender-affirming hormone therapy: An updated literature review with an eye on the future

In line with increasing numbers of transgender (trans) and gender nonbinary people requesting hormone treatment, the body of available research is expanding. More clinical research groups are presenting data, and the numbers of participants in these studies are rising. Many previous review papers have focused on all available data, as these were scarce, but a more recent literature review is timely. Hormonal regimens have changed over time, and older data may be less relevant for today's practice. In recent literature, we have found that even though mental health problems are more prevalent in trans people compared to cisgender people, less psychological difficulties occur, and life satisfaction increases with gender-affirming hormone treatment (GAHT) for those who feel this is a necessity. With GAHT, body composition and contours change towards the affirmed sex. Studies in bone health are reassuring, but special attention is needed for adolescent and adult trans women, aiming at adequate dosage of hormonal supplementation and stimulating therapy compliance. Existing epidemiological data suggest that the use of (certain) estrogens in trans women induces an increased risk of myocardial infarction and stroke, the reason that lifestyle management can be an integral part of trans health care. The observed cancer risk in trans people does not exceed the known cancer-risk differences between men and women. Now it is time to integrate the mostly reassuring data, to leave the overly cautious approach behind, to not copy the same research questions repeatedly, and to focus on longer follow-up data with larger cohorts.

Automated summary

With increasing demand for hormone treatment among transgender and gender nonbinary individuals, more research data is becoming available. A recent literature review found that gender-affirming hormone treatment can lead to increased life satisfaction and reduced psychological difficulties for those who feel it is necessary. The use of hormones can also change body composition and contours. Studies on bone health have shown reassuring results, but special attention is needed for adolescent and adult trans women in terms of hormone dosage and treatment compliance. The use of certain estrogens in trans women may increase the risk of myocardial infarction and stroke, highlighting the importance of lifestyle management in trans healthcare.