期刊
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
卷 41, 期 12, 页码 469-476出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2021.0057
关键词
chimeric antigen receptor T cells; cytokine release syndrome; acute lymphoblastic leukemia; non-Hodgkin lymphoma; prognosis
资金
- Wenzhou Municipal Science and Technology Bureau [2018ZY014]
- Zhejiang Provincial Natural Science Foundation of China [LY20H080005]
- First Affiliated Hospital of Wenzhou Medical University [2018QD009]
This study evaluated the association between cytokine release syndrome (CRS) and efficacy after anti-CD19 CAR-T therapy in 22 patients with relapsed/refractory B cell hematological malignancies. The findings showed that patients with >= grade 2 CRS had higher complete remission rates (CR) and longer progression-free survival (PFS), and bridging hematopoietic stem cell transplantation was another independent predictor for PFS. The data suggested that appropriate CRS may be beneficial to the efficacy of CAR-T therapy.
Cytokine release syndrome (CRS) is the most common on-target toxicity of chimeric antigen receptor (CAR) T cell therapy. However, the prognostic significance of CRS has not been well elucidated. The aim of our study was to evaluate the association between CRS and efficacy after anti-CD19 CAR-T therapy in a retrospective cohort of 22 patients with relapsed/refractory B cell hematological malignancies. The complete remission (CR) rates after CAR-T therapy were 68%, and median value for progression-free survival (PFS) was 6.8 months. Eight of 22 (36.4%) patients showed >= grade 2 CRS. Statistical analysis found that patients with >= grade 2 CRS had higher CR rates and longer PFS than those with < grade 2 CRS. Moreover, bridging hematopoietic stem cell transplantation was another independent predictor for PFS. These data suggested that appropriate CRS may be beneficial to the efficacy of CAR-T therapy. The Clinical Trial Registration number is NCT03110640, NCT03302403.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据