期刊
JOURNAL OF INTEGRATIVE NEUROSCIENCE
卷 21, 期 1, 页码 -出版社
IMR PRESS
DOI: 10.31083/j.jin2101037
关键词
Botulinum toxin; Chronic headache; Chronic migraine; Cluster headache; OnabotulinumtoxinA; Neurotoxin
Botulinum toxin (BT) is a neurotoxin used for the treatment of conditions associated with increased muscle tone, smooth muscle hyperactivity, salivation, sweating, and allergies. Specifically, onabotulinumtoxinA is commonly used for the treatment of chronic pain disorders.
Botulinum toxin (BT) is a neurotoxin produced by Clostridium botulinum, a gram-positive anaerobic bacterium. Systemic human intoxication from BT following oral ingestion results in acute and life-threatening muscle paralysis called botulism. BT has a wide scope of therapeutic uses, including conditions associated with increased muscle tone, smooth muscle hyperactivity, salivation, sweating, and allergies, as well as for cosmetic purposes. Several commercial forms of BT are available for medical use, including Botox (onabotulinumtoxinA). Multiple studies have found evidence of an analgesic effect of onabotulinumtoxinA and demonstrated the benefits of its use for the treatment of various chronic pain disorders. In this review, we provide an update on the use of onabotulinumtoxinA for the treatment of headache disorders.
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