期刊
JOURNAL OF INNATE IMMUNITY
卷 14, 期 3, 页码 167-181出版社
KARGER
DOI: 10.1159/000518679
关键词
Antibiotic resistance; Phagocytosis; Neutrophil; Capsule polysaccharide; Vaccine
类别
资金
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health
The article discusses the characteristics of Klebsiella pneumoniae and its impact on host defense, as well as the challenges of treatment caused by antibiotic resistance and limited treatment options.
Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative commensal bacterium and opportunistic pathogen. In healthy individuals, the innate immune system is adept at protecting against K. pneumoniae infection. Notably, the serum complement system and phagocytic leukocytes (e.g., neutrophils) are highly effective at eliminating K. pneumoniae and thereby preventing severe disease. On the other hand, the microbe is a major cause of healthcare-associated infections, especially in individuals with underlying susceptibility factors, such as pre-existing severe illness or immune suppression. The burden of K. pneumoniae infections in hospitals is compounded by antibiotic resistance. Treatment of these infections is often difficult largely because the microbes are usually resistant to multiple antibiotics (multidrug resistant [MDR]). There are a limited number of treatment options for these infections and new therapies, and preventative measures are needed. Here, we review host defense against K. pneumoniae and discuss recent therapeutic measures and vaccine approaches directed to treat and prevent severe disease caused by MDR K. pneumoniae.
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