4.7 Article

APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 226, 期 5, 页码 891-895

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac003

关键词

Africa; APOBEC3C; editing; hepatitis B virus; nucleotide context; patients; polymorphism

资金

  1. Institut Pasteur
  2. Institut Pasteur International Network [17-2010]
  3. Ligue Contre le Cancer

向作者/读者索取更多资源

This study demonstrates that APOBEC3C(S188I) editing enzyme can enhance the editing activity against HBV. Given the polymorphism of this editing enzyme in African populations and its restriction effect on immunodeficiency viruses, this finding holds significant implications.
In this study, we demonstrated in culture and in patients that HBV could be edited by APOBEC3C(S188I). This enzyme led to an enhanced editing activity in a more specific 5MODIFIER LETTER PRIMETpCpA -> 5MODIFIER LETTER PRIMETpTpA context. This constitutes a new hallmark of APOBEC3C(S188I). Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV) could be edited by APOBEC3C(S188I). Using next-generation sequencing, we demonstrated that APOBEC3C(S188I) led to enhanced editing activity in 5MODIFIER LETTER PRIMETpCpA -> 5MODIFIER LETTER PRIMETpTpA context. This constitutes a new hallmark of this enzyme, which could be used to determine its impact on HBV or nuclear DNA.

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