期刊
JOURNAL OF INFECTIOUS DISEASES
卷 225, 期 12, 页码 2229-2234出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac054
关键词
latent tuberculosis; type-2 diabetes mellitus; heterologous immunity; inflammatory diseases; innate immunity; low-grade inflammation
资金
- Swiss National Science Foundation (SNF) [177499, 201369, P 880]
- SNF [179571, BSSGI0_155851, 310030_200407]
- Swiss HIV Research Foundation.
- Swiss National Science Foundation (SNF) [310030_200407] Funding Source: Swiss National Science Foundation (SNF)
This study investigated the link between LTBI and DM in people living with HIV. The results showed that LTBI significantly increased the risk of developing DM, which was robust across different adjustment and censoring techniques.
While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.
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