4.2 Article

Extreme gonococcal susceptibility associated with acquired complement deficiency secondary to hypocomplementemic urticarial vasculitis and systemic lupus erythematosus

期刊

JOURNAL OF INFECTION AND CHEMOTHERAPY
卷 28, 期 2, 页码 308-310

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ELSEVIER
DOI: 10.1016/j.jiac.2021.10.020

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Neisseria gonorrhoeae; Susceptibility; Systemic lupus erythematosus; Hypocomplementemic urticarial vasculitis; Vaccination

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This article describes a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discusses the implications of profound acquired complement deficiency secondary to these autoimmune diseases. The case raises the question of systematic antibiotic prophylaxis in patients with acquired complement deficiency.
Gonococcal infection is rarely associated with septic shock. We describe a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discuss the implication of profound acquired complement deficiency secondary to these auto-immune diseases. This case raises the question of systematic antibioprophylaxis in patients with acquired complement deficiency.

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