Immunocompromised children and young people are at no increased risk of severe COVID-19

Article Allergy

COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

Adrian M. Shields et al.

Summary: Patients with PID and symptomatic SID have higher morbidity and mortality risks from COVID-19 compared to the general population, requiring enhanced protective measures.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Pediatrics

Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States

L. Charles Bailey et al.

Summary: This cohort study of US pediatric patients found low rates of SARS-CoV-2 infection, with mild clinical manifestations. Infection was associated with Black, Hispanic, and Asian race/ethnicity, adolescence and young adulthood, as well as non-respiratory chronic medical conditions. The study suggests higher concern may be warranted for patients with complex medical conditions or minority race/ethnicity.

JAMA PEDIATRICS (2021)

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Review Infectious Diseases

Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis

Boyan K. Tsankov et al.

Summary: Children with comorbidities are at higher risk of severe COVID-19 infection and associated mortality, with a significantly increased risk compared to healthy children. Obese children also have a higher risk of COVID-19 infection.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Pediatrics

Impact of COVID-19 on Pediatric Immunocompromised Patients

James A. Connelly et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2021)

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Article Infectious Diseases

Seroprevalence of anti-SARS-CoV-2 antibodies after the second pandemic peak

Silvia Stringhini et al.

LANCET INFECTIOUS DISEASES (2021)

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Article Microbiology

Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA

Brittany K. Smith et al.

Summary: This study estimated the seroprevalence of IgG antibodies against SARS-CoV-2 in the St. Louis metropolitan area from April to May 2020. The results showed that 1.7% to 3.1% of individuals had antibodies, indicating previous infection, and the extent of infection was about 10 times greater than confirmed cases. By 5 years of age, children were infected to a similar extent as adults.

MSPHERE (2021)

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Letter Pediatrics

Children and young people remain at low risk of COVID-19 mortality

Sunil S. Bhopal et al.

Summary: Although we used estimates from the Global Burden of Disease 2017 database to accurately represent the reality in these countries, it does not consider seasonality or changes in mortality patterns in this pandemic year. Nonetheless, the very low mortality we describe from COVID-19 compared with all-causes is likely to be accurate.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Article Gastroenterology & Hepatology

Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab

Nicholas A. Kennedy et al.

Summary: The study found that patients with inflammatory bowel disease treated with infliximab had attenuated serological responses to SARS-CoV-2 infection. Additionally, the serological response to SARS-CoV-2 infection in the infliximab-treated group was further blunted by concomitant use of immunomodulators.

GUT (2021)

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Article Medicine, General & Internal

Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study

Zhenyu He et al.

LANCET (2021)

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Article Urology & Nephrology

Detection of SARS-CoV-2 antibodies in pediatric kidney transplant patients

Alanoud Alshami et al.

Summary: The seroprevalence of SARS-CoV-2 was relatively high (11.1%) in the pediatric kidney transplant population, with patients mounting a strong humoral immune response that persisted for a few months despite being on triple immunosuppressants. These findings have positive implications regarding vaccination efficacy in this group.

BMC NEPHROLOGY (2021)

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Article Medicine, General & Internal

COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study

Meera Shaunak et al.

Summary: During the SARS-CoV-2 pandemic in the UK, symptoms compatible with infection were common in immunocompromised children and young people, but no positive tests were found in this large cohort. High levels of anxiety about SARS-CoV-2 infection were reported among participants and parents.

BMJ OPEN (2021)

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Letter Allergy

Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity

Cinzia Milito et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Medicine, General & Internal

Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

Lyudmyla Kompaniyets et al.

Summary: This study investigated the risk of severe COVID-19 illness among children with underlying medical conditions and medical complexity. It found that children with type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity had a higher risk of severe COVID-19 illness, highlighting the importance of close observation and cautious clinical management for these children.

JAMA NETWORK OPEN (2021)

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Article Infectious Diseases

Immunocompromised Seroprevalence and Course of Illness of SARS-CoV-2 in One Pediatric Quaternary Care Center

Megan Culler Freeman et al.

Summary: The seroprevalence of antibodies to SARS-CoV-2 in immunocompromised children is similar to that in immunocompetent children, suggesting an adequate antibody response. However, the illness course in these children may not be severe even if they do test positive for antibodies or via NP RT-PCR.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

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Article Pediatrics

Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study

Thomas Waterfield et al.

Summary: This study found that children had similar antibody responses to SARS-CoV-2 regardless of age, with fatigue, gastrointestinal symptoms, and changes in sense of smell or taste being the symptoms most strongly associated with SARS-CoV-2 antibody positivity.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

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Editorial Material Medicine, General & Internal