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Letter
Medicine, General & Internal
Wanwisa Dejnirattisai et al.
Article
Multidisciplinary Sciences
Elisabetta Cameroni et al.
Summary: The Omicron variant of SARS-CoV-2 has raised concerns due to its 37 amino acid substitutions in the spike protein, particularly in the receptor-binding domain (RBD), leading to increased binding affinity with human ACE2. Neutralizing activity against Omicron was greatly reduced in convalescent and vaccinated individuals compared to the ancestral virus, but this decrease was less significant after a third vaccine dose. Broadly neutralizing monoclonal antibodies recognizing conserved RBD epitopes may be crucial in combating the Omicron variant and future zoonotic transmissions.
Review
Cell Biology
Cody B. Jackson et al.
Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dhiraj Mannar et al.
Summary: The newly reported Omicron variant shows new salt bridges and hydrogen bonds formed by mutated residues in the receptor binding domain, compensating for reduced ACE2 binding affinity. It also exhibits increased antibody evasion, which likely contributes to its rapid spread.
Article
Cell Biology
Shuai Wang et al.
Summary: This study found that AXL may serve as a novel receptor for SARS-CoV-2, playing an important role in promoting viral infection of the human respiratory system. AXL expression level is closely correlated with SARS-CoV-2 S level and could be a potential target for future clinical intervention strategies.
Review
Biochemistry & Molecular Biology
Aaya Nassar et al.
Summary: The novel coronavirus causing the COVID-19 pandemic has become a global health and economic burden, understanding how the virus binds to host-cell receptors is crucial for vaccine and treatment development against the virus. Extensive research is needed to identify potential viral inhibitors by mapping the virus's cell entry pathways.
Article
Infectious Diseases
Jacques Fantini et al.
Summary: This study aimed to predict the transmissibility of SARS-CoV-2 variants by analyzing genomic sequence data. The researchers found that the NTD and RBD domains of the spike protein synergistically affect virus adhesion, leading to mutations in both domains in most variants. They introduced a transmissibility index (T-index) based on the kinetic and affinity parameters of coronavirus binding to host cells, which can predict the dissemination of each variant in animal and human populations.
JOURNAL OF INFECTION
(2021)
Article
Infectious Diseases
Ibrahim M. Ibrahim et al.
JOURNAL OF INFECTION
(2020)
