Improving pharmacologically relevant properties of sulfasalazine loaded in y-cyclodextrin-based metal organic framework

The aim of this work was to improve the dissolution properties of poorly soluble drug sulfasalazine (SSZ) by encapsulation in the metal organic framework based on y-cyclodextrin (yCD-MOF). Loading of SSZ in the framework was successfully performed by impregnation and co-crystallization methods. The obtained composites yCD-MOF/SSZ were investigated by several methods, including PXRD, N2 physisorption, FTIR, solid 13C NMR, SEM, and DLS. The SSZ release from yCD-MOF was examined with in vitro dissolution studies using simulated gastric and intestinal fluids. Sulfasalazine loaded in yCD-MOF exhibited the improved release. Release profiles of SSZ were compared and analyzed using different kinetic models. Some efforts were made to reduce the burst release of SSZ from yCD-MOF in the phosphate buffer (pH 6.8). Influence of y-cyclodextrin on the membrane permeability of SSZ was examined. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Automated summary

This study aimed to improve the dissolution properties of poorly soluble drug SSZ by encapsulating it in γCD-MOF, which was successfully achieved through impregnation and co-crystallization methods. Characterization and release behavior of the obtained composites were investigated using various methods, showing significantly improved release of SSZ from γCD-MOF. Different release kinetic models were compared and analyzed.