4.6 Review

Innate Immune Memory and the Host Response to Infection

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Summary: Trained immunity refers to the long-term inflammatory phenotypes adopted by innate immune cells following brief encounters with exogenous or endogenous stimuli. This phenomenon can enhance host defense against infections but may also be maladaptive in chronic inflammatory disorders. Understanding the mechanisms driving trained immunity, including changes in intracellular metabolism and epigenetic reprogramming, is crucial for future therapeutic exploitation.

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