☆ 4.6 Article

Comprehensive Immune Profiling Reveals CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease

JOURNAL OF IMMUNOLOGY (2022)

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添加到收藏夹

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Claudia Papewalis et al.

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添加到收藏夹

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添加到收藏夹

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Olof Grip et al.

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添加到收藏夹

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Jane Kelly-Rogers et al.

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添加到收藏夹

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RF Chen et al.

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