期刊
JOURNAL OF HUMAN NUTRITION AND DIETETICS
卷 35, 期 4, 页码 651-662出版社
WILEY
DOI: 10.1111/jhn.12958
关键词
CETP Taq1B polymorphism; dietary indices; metabolic biomarkers; T2DM
资金
- Tehran University of Medical Sciences [92-03-161-24464]
The study found significant interactions between CETP Taq1B gene polymorphism and dietary indices on various metabolic biomarkers, such as LDL/HDL, total antioxidant capacity, pentraxin 3, waist circumference, and interleukin-18. These results suggest the combined effects of genetic and dietary factors on metabolic health in T2DM patients.
Background Type 2 diabetes mellitus (T2DM) is a multidimensional consequence of environmental and genetic factors. Cholesteryl ester transfer protein (CETP) Taq1B polymorphism has been reported as a main predictor of dyslipidaemia, comprising an important complication in persons with T2DM. However, diet could affect T2DM patients metabolic health. Methods We investigated the combination of gene-diet effects on some metabolic biomarkers. In our cross-sectional study, blood samples of 220 patients were collected. Dietary indices (healthy eating index, dietary quality index and dietary phytochemical index) were obtained from a validated semi-quantitative food frequency questionnaire. CETP Taq1B polymorphism was genotyped by a polymerase chain reaction-restriction fragment polymorphism method. Data were analysed by analysis of covariance. Results The interaction between the CETP Taq1B polymorphism and dietary indices on low density lipoprotein/high density lipoprotein was significant (p < 0.001 both crude and adjusted models). In addition, the interaction between polymorphism and dietary quality index on total antioxidant capacity (p = 0.004 crude model, p = 0.005 after adjusting) and pentraxin 3 (p = 0.01 both crude and adjusted models) was significant. Also, the interaction between polymorphism and healthy eating index on waist circumference (p = 0.005 both crude and adjusted models) and dietary phytochemical index on interleukin-18 (p = 0.03 crude model) was significant. Conclusions Our results indicated the effect of CETP Taq1B polymorphism on some inflammatory and anthropometrics markers (total antioxidant capacity, pentraxin 3, interleukin-18, low density lipoprotein/high density lipoprotein and waist circumference) with high and low adherence to dietary incides.
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