Microwave assisted synthesis of N-substituted acridine-1,8-dione derivatives: Evaluation of antimicrobial activity

A simple and convenient one-pot method for the synthesis of N-substituted acridine derivatives from the condensation of 1,3-cyclohexanedione, substituted aryl amines, and 1,2,3-triazole aldehydes using a mixture of water/ethanol as a reaction medium is reported. The current protocol delivers numerous advantages such as good yields, short reaction time, easy work-up, and simplicity in the procedure as it uses a green method and an eco-friendly catalyst. The target compounds are screened for their in vitro antimicrobial activity and most of the compounds are found to exhibit promising activity compared to standard drugs. The docking studies carried out using Autodock 4.2 were proven that all the molecules exhibited good interactions with protein glucosamine-6-phosphate synthase of Escherichia Coli and the secreted aspartic proteinase from Candida albicans and the docking results are in well agreement with antimicrobial activity.

Automated summary

In this study, a simple and convenient method for the synthesis of N-substituted acridine derivatives was developed. The method exhibited good yields, short reaction time, and easy operation, while using an eco-friendly catalyst. The synthesized compounds showed promising antimicrobial activity, which was further supported by docking studies that demonstrated good interactions with specific proteins.