Synthesis of new 1H-spiro[acridine-9,3′-indoline]-1,2′(2H,10H)-dione derivatives using aqueous ethanol as a reaction medium

One-pot three component synthesis of novel spiro[acridine-9,3 '-indoline]-1,2 '(2H,10H)-dione derivatives has been performed through the condensation of isatin, dimedone, and aniline under greener conditions. The remarkable features of this synthesis are use of ethanol:water mixture as a greener solvent and isolation of products by simple washing with water. The structures of the synthesized compounds have been well elucidated by various spectroscopic techniques.

Automated summary

A one-pot three component synthesis of novel spiro[acridine-9,3 '-indoline]-1,2 '(2H,10H)-dione derivatives has been successfully achieved under greener conditions, by condensing isatin, dimedone, and aniline. The notable features of this synthesis include the use of a greener solvent (ethanol:water mixture) and the isolation of products by a simple water washing method. The structures of the synthesized compounds have been thoroughly elucidated through various spectroscopic techniques.