4.4 Article

One pot synthesis of α-N-heteroaryl ketone derivatives from aryl ketones using aqueous NaICl2

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JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 59, 期 4, 页码 800-803

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WILEY
DOI: 10.1002/jhet.4412

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A simple and efficient method using aqueous sodium dichloroiodate has been established for the synthesis of alpha-heteroaryl ketones from aryl ketones and amine. This method is mild, operationally simple, with a short reaction time, and yields moderate to good amounts of alpha-N-heteroaryl ketone derivatives.
A simple and efficient method for the synthesis of alpha-heteroaryl ketones from aryl ketones and amine using aqueous sodium dichloroiodate is established. This method is mild, operationally simple, has a short reaction time, and easy workup procedure to afford the corresponding alpha-N-heteroaryl ketone derivatives in moderate to good yield.

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