4.7 Review

STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer

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Summary: IL-6 is involved in various physiological processes including immune responses and inflammation. It plays a crucial role in chronic inflammation and cytokine storms, such as seen in COVID-19. The IL-6 amplifier, involving NF-kappa B and STAT3, is a key mechanism in promoting uncontrolled inflammatory responses.

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Kevin R. Gillinder et al.

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Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons

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Serine-727 Phosphorylation Activates Hypothalamic STAT-3 Independently From Tyrosine-705 Phosphorylation

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Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

Maupali Dasgupta et al.

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Toward a new STATe: The role of STATs in mitochondrial function

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JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells

Arata Nishimoto et al.

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Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

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Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function

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Acetylation modulates the STAT signaling code

Martin Wieczorek et al.

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Mechanisms of Unphosphorylated STAT3 Transcription actor Binding to DNA

Olga A. Timofeeva et al.

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Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Daniel J. Gough et al.

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P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNγ

Rossitza Christova et al.

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STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas

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The JAK-STAT signaling pathway: Input and output intergration

Peter J. Murray

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JAK signaling globally counteracts heterochromatic gene silencing

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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3

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Genome-wide analysis of the GRAS gene family in rice and Arabidopsis

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Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

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Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein

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