期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 419, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.126409
关键词
Tetravalent tin; Dichromate; Fluorescence sensor; Cancer cells; Intracellular imaging
资金
- Medical Research Center Program through the National Research Foundation (NRF) - Korean government (MSIP) [NRF-2017R1A5A2015061]
- Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Ministry of Trade, Industry & Energy (MOTIE) of the Republic of Korea [20184030202210]
This study successfully fabricated a new low-cost, easy-to-prepare dual-channel fluorescence chemosensor NDA for remarkable Sn4+ detection in water and biological medium, showing excellent performance characteristics. It was also utilized as a biomarker for tracking Sn4+ in human cancer cells with distinguished recognition compared to normal live cells.
The goal of the present work was to fabricate a new low-cost, easy-to-prepare, dual-channel fluorescence chemosensor comprised of acridine-diphenylacetyl moieties (NDA) to enable remarkable Sn4+ detection in water and biological medium. The resulting NDA-Sn4+ complex was utilized for the distinguished identification of Cr2O72- ions from other anions and biomolecules. These investigations involve the absorption, fluorescence, and electrochemical methods for the detection of Sn4+ and Cr2O72- ions in pure water. The mechanism for NDA-mediated Sn4+ detection was experimentally determined by FT-IR, NMR titrations, mass (ESI) analyses, and DFT calculations. The obtained results indicate that the NDA chemosensor possessed excellent performance characteristics including good water solubility and compatibility, quick response time (less than 10 s), high sensitivity (Sn4+ = 0.268 mu M and Cr2O72- = 0.160 mu M), and selectivity against coexisting metals, anions, amino acids, and peptides. The chemosensor NDA induced negligible toxicity in live cells and was successfully utilized as a biomarker for the tracking of Sn4+ in human normal and cancer cells. More importantly, NDA demonstrates distinguished recognition of Sn4+ in human cancer cells rather than in normal live cells. Additionally, NDA was shown to act as a mitochondria-targeted probe in FaDu cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据