期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 37, 期 2, 页码 335-341出版社
WILEY
DOI: 10.1111/jgh.15705
关键词
curcumin; functional dyspepsia; HRQOL; omeprazole
资金
- Gastroenterological Association of Thailand (GAT)
The study showed that Curcuma longa Linn can improve dyspeptic symptoms, enhance quality of life, and provide satisfaction comparable to omeprazole in the treatment of functional dyspepsia.
Background and Aims Functional dyspepsia (FD) is a common problem in gastroenterology practice. The study aimed to compare the efficacy of Curcuma longa Linn versus omeprazole and placebo among patients diagnosed with FD. Methods From November 2017 to November 2018, patients diagnosed with FD according to ROME IV criteria were enrolled. Patients were randomized into curcumin, omeprazole, or placebo groups. The Severity of Dyspepsia Assessment (SODA) was used to evaluate clinical effectiveness after 2 and 4 weeks. Health-related quality of life was assessed using the EuroQol-5 Dimension questionnaire. Results A total of 132 patients were randomized. Forty-five, 43, and 44 patients were in the curcumin, omeprazole, and placebo groups, respectively. At 4 weeks, the mean SODA score change of pain and non-pain symptoms decreased in the curcumin group compared with the placebo group (pain -16.98 +/- 8.09 vs -10.53 +/- 4.43; P < 0.001, non-pain -7.96 +/- 3.41 vs -6.05 +/- 3.03; P < 0.008). No significant difference was observed between curcumin and omeprazole groups (pain -16.98 +/- 8.09 vs -14.69 +/- 6.41; P = 0.302, non-pain -7.96 +/- 3.41 vs -7.07 +/- 2.27; P = 0.486). The mean change of the SODA satisfaction score at 4 weeks was higher in the curcumin group compared with the omeprazole group but without statistical significance (9.17 +/- 3.88 vs 8.63 +/- 3.89, P = 1). The mean change of EQ-5D index at 4 weeks was highest in the curcumin group but not statistically different from other groups (0.12 +/- 0.13 vs 0.09 +/- 0.10 vs 0.07 +/- 0.05; P = 0.055). Conclusion Curcuma longa Linn can improve dyspeptic symptoms, improve quality of life, and provide satisfaction equivalent to omeprazole in treatment of FD.
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