期刊
JOURNAL OF GASTROENTEROLOGY
卷 57, 期 3, 页码 174-184出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00535-022-01851-1
关键词
COVID-19; SARS-CoV-2; Inflammatory bowel disease; Steroid; Anti-TNF-alpha antibodies
资金
- Ministry of Health, Labour and Welfare of Japan
The incidence of COVID-19 among Japanese IBD patients was low, with most patients being in clinical remission and only a small number of severe cases. Age, BMI, and steroid use were identified as independent risk factors for COVID-19 severity in Japanese IBD patients.
Background The spread of coronavirus disease 2019 (COVID-19) had a major impact on the health of people worldwide. The clinical background and clinical course of inflammatory bowel disease (IBD) among Japanese patients with COVID-19 remains unclear. Methods This study is an observational cohort of Japanese IBD patients diagnosed with COVID-19. Data on age, sex, IBD (classification, treatment, and activity), COVID-19 symptoms and severity, and treatment of COVID-19 were analyzed. Results From 72 participating facilities in Japan, 187 patients were registered from June 2020 to October 2021. The estimated incidence of COVID19 in Japanese IBD patients was 0.61%. The majority of IBD patients with COVID-19 (73%) were in clinical remission. According to the WHO classification regarding COVID-19 severity, 93% (172/184) of IBD patients had non-severe episodes, while 7% (12/184) were severe cases including serious conditions. 90.9% (165/187) of IBD patients with COVID-19 had no change in IBD disease activity. A logistic regression analysis stepwise method revealed that older age, higher body mass index (BMI), and steroid use were independent risk factors for COVID-19 severity. Six of nine patients who had COVID-19 after vaccination were receiving antitumor necrosis factor (TNF)-alpha antibodies. Conclusion Age, BMI and steroid use were associated with COVID-19 severity in Japanese IBD patients.
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