期刊
JOURNAL OF FOOD SCIENCE
卷 87, 期 3, 页码 1268-1281出版社
WILEY
DOI: 10.1111/1750-3841.16076
关键词
Bentong ginger oleoresin; gut microbiota; high-fat diet; nonalcoholic fatty liver disease
资金
- China Special Fund for Agro-scientific Research in the Public Interest [201503142]
- China Agricultural University Education Foundation
This study aimed to investigate the effects of Bentong ginger oleoresin (BGO) on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. The results showed that BGO treatment reduced obesity induced by a high-fat diet (HFD), decreased serum total cholesterol levels, and improved liver fat accumulation. Furthermore, BGO exhibited anti-inflammatory activity and regulated the gut microbiota in NAFLD mice. These findings suggest that BGO may serve as an effective dietary supplement for the improvement of NAFLD-related metabolic diseases.
The present study aimed to examine the protective effect of Bentong ginger oleoresin (BGO) on the occurrence of nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. In the present study, 14-week BGO treatment reduced the high-fat diet (HFD)-induced obesity. The serum total cholesterol (TC) was reduced from 4.76 +/- 0.30 to 3.542 +/- 0.49 mmol/L and fatty liver score decreased to the normal level (1.6 +/- 0.55). BGO had antihypercholesterolemia activity, alleviated abnormal lipid metabolism, and improved liver fat accumulation. In addition, liver inflammatory cytokine tests and Western blotting analysis indicated that BGO might play an anti-inflammatory role by mediating the NF-kappa B signaling pathway. Moreover, BGO regulated the gut microbiota in NAFLD mice and finally mediated their benefits for the host, which might be associated with reduced abundance of Lachnospiraceae_NK4A136_group and Fournierella. BGO showed effective liver protection and regulation of gut microbiota for the HFD-induced NAFLD in obese mice. As a result, BGO may serve as an effective dietary supplement for the improvement of NAFLD-related metabolic diseases. Practical Application This study provides a new way to improve the added value of Bentong ginger. It also provides certain experimental data on BGO as a kind of the functional food ingredient. The current work also provides new ideas for the improvement and treatment of NAFLD.
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