4.5 Article

Epigallocatechin-3-gallate inhibits replication of white spot syndrome virus in the freshwater crayfish Procambarus clarkii

期刊

JOURNAL OF FISH DISEASES
卷 45, 期 3, 页码 445-450

出版社

WILEY
DOI: 10.1111/jfd.13573

关键词

crayfish; epigallocatechin-3-gallate; Procambarus clarkii; white spot syndrome virus

资金

  1. Shanghai Science and Technology Innovation Action Plan [17391902100]
  2. Function Laboratory for Marine Fisheries Science and Food Production Processes [2019-BH-B02]
  3. China Agriculture Research System of MOF and MARA [CARS-45-19]

向作者/读者索取更多资源

The study showed that different concentrations of EGCG can suppress WSSV infection in P. clarkii, with histopathological examination revealing no characteristic pathological changes in P. clarkii tissues due to EGCG administration. Pharmacokinetics studies demonstrated rapid absorption of EGCG in P. clarkii, with peak concentrations of 73.78 μg/g in the liver and 24.87 μg/g in the muscle. The results indicate the high potential applications of EGCG against WSSV in P. clarkii.
The freshwater crayfish Procambarus clarkii is native to North America and Mexico, and it was introduced to China in 1929. The production and consumption of P. clarkii in China are the highest worldwide, reaching 208.96 million tons in 2020. The white spot syndrome virus (WSSV) is a major pathogen that affects shrimp, crayfish, crabs and lobsters, and it has caused widespread loss to the P. clarkii industry. Epigallocatechin-3-gallate (EGCG), a small-molecule compound, has a multitude of biological functions and the ability to bind to the 37 kDa/67 kDa laminin receptor (LamR). EGCG has potential antiviral effects against WSSV. In this study, we evaluated the potential anti-WSSV applications of EGCG in P. clarkii. We demonstrated that various concentrations (10 mu g/g center dot bw, 20 mu g/g center dot bw and 40 mu g/g center dot bw) of EGCG can suppress WSSV infection in P. clarkii. Histopathological examination revealed no characteristic pathological changes due to EGCG administration in P. clarkii tissues. Furthermore, pharmacokinetics studies of EGCG in P. clarkii revealed its rapid absorption (T-max = 2 h), and the peak concentrations of EGCG were 73.78 mu g/g in the liver and 24.87 mu g/g in the muscle. Our results indicate the high potential applications of EGCG against WSSV in P. clarkii.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据