4.7 Article

CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases

期刊

JOURNAL OF EXPERIMENTAL MEDICINE
卷 219, 期 2, 页码 -

出版社

ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20211191

关键词

-

资金

  1. National Natural Science Foundation of China [31725010, 31821003, 31991174, 32030037]
  2. Ministry of Science and Technology of the Peoples Republic of China [2020YFA0509100]
  3. Chongqing Health Commission [2020NCPZX01]
  4. Tsinghua University COVID-19 Scientific Research Program [2020Z99CFZ024]
  5. Tsinghua-Peking Center for Life Sciences

向作者/读者索取更多资源

Zhang et al. analyzed the functional heterogeneity of human monocytes in acute and chronic inflammatory disease conditions. They discovered a subset of CD127(+) hypoinflammatory monocytes within the inflammatory environment, suggesting the important role of CD127 in imprinting functional diversity in human monocytes. The study also found that CD127 marked a subset of monocytes/macrophages with hypoinflammatory phenotypes in COVID-19 and rheumatoid arthritis.
Zhang et al. analyzed human monocytes in acute and chronic inflammatory disease conditions with multiomics approaches and identified a subset of CD127(+) hypoinflammatory monocytes within the inflammatory environment, uncovering functional heterogeneity of human inflammatory monocytes imprinted by CD127. Inflammatory monocytes are key mediators of acute and chronic inflammation; yet, their functional diversity remains obscure. Single-cell transcriptome analyses of human inflammatory monocytes from COVID-19 and rheumatoid arthritis patients revealed a subset of cells positive for CD127, an IL-7 receptor subunit, and such positivity rendered otherwise inert monocytes responsive to IL-7. Active IL-7 signaling engaged epigenetically coupled, STAT5-coordinated transcriptional programs to restrain inflammatory gene expression, resulting in inverse correlation between CD127 expression and inflammatory phenotypes in a seemingly homogeneous monocyte population. In COVID-19 and rheumatoid arthritis, CD127 marked a subset of monocytes/macrophages that retained hypoinflammatory phenotypes within the highly inflammatory tissue environments. Furthermore, generation of an integrated expression atlas revealed unified features of human inflammatory monocytes across different diseases and different tissues, exemplified by those of the CD127(high) subset. Overall, we phenotypically and molecularly characterized CD127-imprinted functional heterogeneity of human inflammatory monocytes with direct relevance for inflammatory diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据