CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

Article Pharmacology & Pharmacy

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Elisa Rioja-Blanco et al.

Summary: This study validates the potential use of T22-GFP-H6 as a nanocarrier to selectively deliver drugs to CXCR4(+) tumors in HNSCC, showing promising therapeutic effects without causing histological alterations in normal organs.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Chemistry, Multidisciplinary

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

Dan Wu et al.

Summary: Pyroptosis, a unique form of programmed cell death, has been closely associated with human diseases like inflammatory diseases and malignant tumors. Recent progress in cancer treatment based on nanoparticles-induced pyroptosis highlights design features and therapeutic advantages, while also proposing future directions in this emerging area.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Biochemistry & Molecular Biology

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

Kohsuke Tsuchiya

Summary: Pyroptosis is a regulated form of cell death, executed by Gasdermines (GSDMs) that form pores in the plasma membrane leading to cell lysis. Pyroptotic cells release pro-inflammatory molecules, eliciting inflammation and immune responses. Recent studies have advanced our understanding of pyroptosis mechanisms and roles, which may aid in the development of cancer immunotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice

Laia Canes et al.

Summary: Drug therapy for limiting abdominal aortic aneurysm growth or rupture is currently ineffective, and there is incomplete understanding of disease biology. The nuclear receptor NOR-1 plays a role in AAA by amplifying the vascular response to Ang II, leading to vascular inflammation, MMP activity increase, and elastin integrity disturbance. Overexpression of NOR-1 in vascular smooth muscle cells in mice models strengthens the response to Ang II, contributing to the formation of AAA.

HYPERTENSION (2021)

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Review Cell Biology

Cell death in head and neck cancer pathogenesis and treatment

Martina Raudenska et al.

Summary: Many cancer therapies target apoptosis in cancer cells, but the presence of oncogenic alterations and tumor microenvironment composition limit their efficacy. There are about 10 different cell death subroutines that cancer cells cannot avoid, highlighting the need for individualized therapy. Understanding the molecular heterogeneity of tumors and their cell death pathways is crucial for improving treatment response.

CELL DEATH & DISEASE (2021)

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Review Oncology

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Lei Wang et al.

Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers

Yuzuka Kanno et al.

Summary: This review discusses the molecular mechanisms of chemotherapy resistance in head and neck cancer and potential strategies for improving treatment outcomes, suggesting combination therapies with immunotherapy may be beneficial for prolonging survival.

FRONTIERS IN ONCOLOGY (2021)

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Review Immunology

Recent development and optimization of pseudomonas aeruginosa exotoxin immunotoxins in cancer therapeutic applications

Tong Wu et al.

Summary: Recombinant immunotoxins are fusion proteins designed through genetic recombination, consisting of a peptide toxin and a targeting domain to recognize disease-specific receptors and induce cell death. Efforts are ongoing to address challenges such as immunogenicity and non-specific cytotoxicity, with recent strategies for structural optimization and mutagenesis showing promise in enhancing safety and efficacy. These immunotoxins are expected to play a crucial role in cancer therapy, with continuous advancements in design concepts and development prospects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Oncology

Therapeutic Potential of Antibody-Drug Conjugate-Based Therapy in Head and Neck Cancer: A Systematic Review

Vittoria Perrotti et al.

Summary: Despite advancements in understanding molecular mechanisms and developing new therapies for head and neck cancer, the disease remains challenging, with a relatively low 5-year survival rate and limited representation in clinical trials. Targeted therapies tailored for the HNC phenotype may offer new treatment perspectives.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

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A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

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A novel 3′,5′-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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NATURE (2020)

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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Xiaowei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

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Article Medicine, General & Internal

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Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Cell Biology

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

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CELL DEATH DISCOVERY (2020)

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Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

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A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

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EBIOMEDICINE (2019)

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Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

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CELL DEATH & DISEASE (2019)

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The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

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JOURNAL OF CONTROLLED RELEASE (2018)

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Article Oncology

SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy

Chiara De-Colle et al.

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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

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Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review

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Review Biochemistry & Molecular Biology

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Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

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UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

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