期刊
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
卷 40, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13046-021-02141-z
关键词
Oxaliplatin-induced peripheral neuropathy; Clinical syndrome; Molecular basis; Drug development; Oxidative stress; Gut microbiota
类别
资金
- National Natural Science Foundation of China [81973498, 81774283]
- National Science Foundation For Distinguished Young Scholars [82125037]
- Joint Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical Group [JKLPSE202003]
- Suzhou Clinical Key Disease Diagnosis and Treatment Technology foundation [LCZX201823]
- Suzhou Science and Technology Development Program [SYS2020058]
- Changshu Science and Technology Development Program [CS202029]
OIPN is a severe clinical problem and potentially permanent side effect of cancer treatment, with complex molecular mechanisms and limited treatment options. Recent studies focus on prevention and treatment methods, emphasizing close collaboration between clinical teams and oncologists.
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and potentially permanent side effect of cancer treatment. For the management of OIPN, accurate diagnosis and understanding of significant risk factors including genetic vulnerability are essential to improve knowledge regarding the prevalence and incidence of OIPN as well as enhance strategies for the prevention and treatment of OIPN. The molecular mechanisms underlying OIPN are complex, with multi-targets and various cells causing neuropathy. Furthermore, mechanisms of OIPN can reinforce each other, and combination therapies may be required for effective management. However, despite intense investigation in preclinical and clinical studies, no preventive therapies have shown significant clinical efficacy, and the established treatment for painful OIPN is limited. Duloxetine is the only agent currently recommended by the American Society of Clinical Oncology. The present article summarizes the most recent advances in the field of studies on OIPN, the overview of the clinical syndrome, molecular basis, therapy development, and outlook of future drug candidates. Importantly, closer links between clinical pain management teams and oncology will advance the effectiveness of OIPN treatment, and the continued close collaboration between preclinical and clinical research will facilitate the development of novel prevention and treatments for OIPN.
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