期刊
出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03601234.2021.2017211
关键词
Veterinary antibiotics; animal-derived food; unintentional ingestion; daily exposure dose; hazard index; HPLC-MS; MS
资金
- National Natural Science Foundation of China [41773121, 11875185, 11775138]
- National Key Research and Development Project [2020YFC1808200]
- Key Laboratory of Organic Compound Pollution Control Engineering (MOE), Shanghai University, Shanghai, P. R. China
The study found that animal-derived foods, especially meat, milk, and eggs, are the main sources of unintentional exposure to antibiotics in humans. People who regularly consume these foods have higher levels of veterinary antibiotics or preferred veterinary antibiotics in their urine, indicating a direct correlation between food consumption and antibiotic intake. Therefore, more attention must be paid to the residues of unnecessary veterinary antibiotics derived from animal-sourced food.
Diet is known to be one of the main sources from which human intake many environmental contaminants, for example, antibiotics. To determine the effect of dietary factors on antibiotic intake, we identified the levels of antibiotics present in the urine of the general population from two regions of Shanghai. Moreover, we assessed the amount of exposure to these substances and the health risks they posed. There were a total of 18 antibiotics, which were sorted into five categories. Based on the above, we used the Food Frequency Questionnaire (FFQ) and demographic data to evaluate the effects of food consumption and demographic factors on levels of the antibiotics in urine. The results found that food sourced from animals had a direct relation to the level of veterinary antibiotics or preferred veterinary antibiotics (VAs/PVAs) detected in urine. Those who regularly consumed, for example, meat, milk and eggs, had considerably more VAs/PVAs in their urine compared to those who didn't. These results demonstrated that animal-derived foods are the main causes of unintentional exposure to antibiotics in human. Our study, therefore, evidenced that more attention must be paid to the residues of unneeded VAs/PVAs derived from animal-sourced food.
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