4.5 Article

Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?

出版社

ELSEVIER
DOI: 10.1016/j.jddst.2021.103057

关键词

Exosomes; Exosome-mimetics; Drug delivery; Nanocarrier; Exosome-based drug delivery; Drug cargo-loading

资金

  1. Ministry of Education, Science and Technological Development of Republic of Serbia [451-03-9/2021-14/200168, 451-03-9/2021-14/200288]

向作者/读者索取更多资源

This article provides an overview of exosome biogenesis, biological role, and purification methods, with a focus on specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. The challenges in translating exosome-based drug carriers to clinical use are also discussed.
Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据