期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 35, 期 12, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2021.108055
关键词
Na-23-MRI; Type 2 diabetes mellitus; Tissue sodium; Vascular remodeling
The study examined the association between tissue sodium content and vascular hypertrophic remodeling in patients with type 2 diabetes, finding significant correlations between sodium content in skin and muscle with vascular structural parameters. The results indicated that tissue sodium content is independently linked to hypertrophic vascular remodeling in type 2 diabetes.
Background: Prospective studies describe a linkage between increased sodium intake and higher incidence of cardiovascular organ damage and end points. We analyzed whether tissue sodium content in the skin and muscles correlate with vascular hypertrophic remodeling, a risk factor for cardiovascular disease. Methods: In patients with type 2 diabetes we assessed tissue sodium content and vascular structural parameters of the retinal arterioles. The structural parameters of retinal arterioles assessed by Scanning Laser Doppler Flowmetry were vessel (VD) and lumen diameter (LD), wall thickness (WT), wall-to-lumen ratio (WLR) and wall cross sectional area (WCSA). Tissue sodium content was measured with a 3.0 T clinical (23)Sodium-Magnetic Resonance Imaging (Na-23-MRI) system. Results: In patients with type 2 diabetes (N = 52) we observed a significant correlation between muscle sodium content and VD (p = 0.005), WT (p = 0.003), WCSA (p = 0.002) and WLR (p = 0.013). With respect to skin sodium content a significant correlation has been found with VD (p = 0.042), WT (p = 0.023) and WCSA (p = 0.019). Further analysis demonstrated that tissue sodium content of skin and muscle is a significant determinant of hypertrophic vascular remodeling independent of age, gender, diuretic use and 24-hour ambulatory BP. Conclusion: With the Na-23-MRI technology we could demonstrate that high tissue sodium content is independently linked to hypertrophic vascular remodeling in type 2 diabetes.
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