AQP5 pathogenic variants induce palmoplantar keratoderma Bothnia type in two Chinese families

Article Biochemistry & Molecular Biology

Molecular dynamics study of water transport through AQP5-R188C mutant causing palmoplantar keratoderma (PPK) using the gating mechanism concept

Hooman Hadidi et al.

Summary: The study found that the disease-causing mutation R188C in aquaporins significantly increases the pore radius, facilitating water molecule passage and improving translocation, resulting in increased permeability. The osmotic permeability of R188C is approximately 11 times that of the wild-type, and the comparison with the open conformation CE suggests that the R188C coefficient more accurately reflects the gating mechanism.

BIOPHYSICAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

A computational model of the epidermis with the deformable dermis and its application to skin diseases

Kota Ohno et al.

Summary: This study presents a three-dimensional computational model of the epidermis that takes into account the deformability of the dermis, showing that the stability of the model depends on the cell supply rate from the basal layer. Additionally, the research investigates how the stiffness of the dermis affects the structure and barrier functions of the epidermis, and simulates the formation of a corn (clavus) by assuming hyperproliferation and rapid differentiation. Experimental data for human corn is provided to support the model assumptions and simulation results.

SCIENTIFIC REPORTS (2021)

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Article Biology