期刊
JOURNAL OF DENTISTRY
卷 113, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2021.103799
关键词
Proteomics; Acquired enamel pellicle; In vivo; Systematic review
资金
- Research Grants Council of the Hong Kong Special Administrative Region, China [17119917]
This study provides a comprehensive review on the proteomic profile of in vivo acquired enamel pellicle, with consistent identification of core proteins related to immune and inflammatory responses across different research groups. Further research is needed to clarify the biological role of AEP in oral health.
Objectives: To provide a comprehensive review on the proteomic profile of in vivo acquired enamel pellicle (AEP) formed on permanent teeth. Data/sources: PubMed, EMBASE (Ovid) and Web of Science databases were searched for eligible studies (up to December 2020). Studies reporting mass spectrometry-based proteomic analysis of in vivo AEP were included. Risk of bias assessment was performed. Qualitative and quantitative proteomic data were extracted, integrated, then followed by bioinformatic analysis. Study selection: Eleven studies were included, involving 122 systemically and dentally healthy adults from four different research groups. Pooled AEP samples from study participants were the normal practice for all included studies. A total of 257/93/108/870 non-redundant proteins were detectable from the in vivo <= 5 min/10-min/60min/2-h AEP samples, respectively. Fifteen core in vivo 2-h AEP proteins, generally associated with immune and/or inflammatory responses, were consistently identifiable from all four research groups. Eight included studies conducted relative quantitative proteomic analysis, while no statistical analysis could be undertaken due to the inherent limitation of the relative quantification in the proteomics analyses of these studies. Conclusions: A systematic review on adult in vivo AEP proteomic profile was undertaken. The results provide a comprehensive appreciation of the AEP proteome in healthy individuals from in vivo sampling. Further studies are warranted to clarify the biological role of AEP on oral health, particularly at an individual level. Clinical significance: A comprehensive appreciation of the proteomic profile of in vivo AEP in healthy individuals is essential to further understand its functions in oral health and disease. The information generated also provides insights for future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据