期刊
JOURNAL OF CROHNS & COLITIS
卷 16, 期 6, 页码 931-939出版社
OXFORD UNIV PRESS
DOI: 10.1093/ecco-jcc/jjab219
关键词
Inflammatory bowel disease [IBD]; dietary patterns; principal component analysis [PCA]; dietary scores; Protein Score; Healthy Eating Index [HEI]; LifeLines Diet Score [LLDS]; Alternate Mediterranean Diet Score [aMED]
资金
- Seerave Foundation
Objective Nutrition plays a role in the development of Crohn's disease [CD] and ulcerative colitis [UC]. The study found that a Western dietary pattern was associated with a greater likelihood of CD development, while a carnivorous pattern was associated with UC development. Additionally, a higher diet quality score was protective against CD development.
Objective Nutrition plays a role in the development of Crohn's disease [CD] and ulcerative colitis [UC]. However, prospective data on nutrition and disease onset are limited. Here, we analysed dietary patterns and scores in relation to inflammatory bowel disease [IBD] development in a prospective population-based cohort. Methods We analysed 125 445 participants of whom 224 individuals developed de novo UC and 97 CD over a maximum 14-year follow-up period. Participants answered health-related [also prospectively] and dietary questionnaires [FFQ] at baseline. Principal component analysis [PCA] was conducted deriving a-posteriori dietary patterns. Hypotheses-based a-priori dietary scores were also calculated, including the protein score, Healthy Eating Index, LifeLines Diet Score [LLDS], and alternative Mediterranean Diet Score. Logistic regression models were performed between dietary patterns, scores, and IBD development. Results PCA identified five dietary patterns. A pattern characterised by high intake of snacks, prepared meals, non-alcoholic beverages, and sauces along with low vegetables and fruit consumption was associated with higher likelihood of CD development (odds ratio [OR]: 1.16, 95% confidence interval [CI]: 1.03-1.30, p = 0.013). A pattern comprising red meat, poultry, and processed meat, was associated with increased likelihood of UC development [OR: 1.11, 95% CI: 1.01-1.20, p = 0.023]. A high diet quality score [LLDS] was associated with decreased risk of CD [OR: 0.95, 95% CI: 0.92-0.99, p = 0.009]. Conclusions A Western dietary pattern was associated with a greater likelihood of CD development and a carnivorous pattern with UC development, whereas a relatively high diet quality [LLDS] was protective for CD development. Our study strengthens the importance of evaluating dietary patterns to aid prevention of IBD in the general population.
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