期刊
JOURNAL OF CONTROLLED RELEASE
卷 338, 期 -, 页码 623-632出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2021.08.062
关键词
Lyotropic liquid crystal gel; Hyaluronic acid; Kartogenin; Cartilage defect regeneration
资金
- National Natural Science Foundation [81773660, 81973263]
- Natural Science Fund Project of Guangdong Province [2020A1515011156, 2018A030310095]
The study showed that HLC gel can improve the rheological properties of the gel, enhance joint protection by increasing mechanical strength, elasticity, and lubrication, prolong drug release and retention in the joint cavity for over 4 weeks, and provide a combined effect of kartogenin and hyaluronic acid for cartilage repair. Pharmacodynamic studies demonstrated that HLC gel was the most effective in promoting chondrogenesis and protecting subchondral bone.
There is a great challenge in regenerating cartilage defects, which usually involve absent bearing capacity and poor adaptation to joint movement, further exacerbating subchondral bone damage. Therefore, ideal tissueengineering cartilage scaffolds should be endowed with biomimetic and sustained-release function for promoting long-term chondrogenesis while protecting subchondral bone. Herein, in situ self-assembling gel based on glyceryl monooleate (GMO)-hyaluronic acid (HA) composite lyotropic liquid crystal (HLC) was developed as the biomimetic scaffold to deliver kartogenin for long-term cartilage regeneration. Compared to the GMO based (LLC) gel, HLC gel with modified lattice structure exhibited improved rheological properties for better joint protection by increasing mechanical strength, elasticity and lubrication. Besides, HLC gel successfully prolonged drug release and retention in the joint cavity over 4 weeks to provide combined effect of kartogenin and HA for cartilage repair. Pharmacodynamic studies demonstrated that HLC gel was the most effective to promote chondrogenesis and protect subchondral bone, making the damaged bone tissue restored to normal in divergent features as evidenced by the MRI, Micro-CT and histological results. Therefore, the HLC gel with joint protection and controlled drug release can serve as a firm scaffold for providing long-term cartilage repair.
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