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Strategy and clinical application of up-regulating cross presentation by DCs in anti-tumor therapy

期刊

JOURNAL OF CONTROLLED RELEASE
卷 341, 期 -, 页码 184-205

出版社

ELSEVIER
DOI: 10.1016/j.jconrel.2021.11.011

关键词

Dendritic cells; Cross presentation; Regulation strategy; Clinical application; Anti-tumor therapy

资金

  1. National Nature Science Foundation of China [81573365, 81973296]
  2. National special fund for major drug development [2017ZX09201004015]

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Dendritic cells play an important role in the cross presentation of exogenous antigens, contributing to a diversified T-cell activation and efficient anti-tumor immune response. Understanding the mechanisms and regulation strategies of cross presentation by DC populations can lead to better clinical efficacy in antitumor therapy.
The cross presentation of exogenous antigen (Ag) by dendritic cells (DCs) facilitates a diversified mode of T-cell activation, orchestrates specific humoral and cellular immunity, and contributes to an efficient anti-tumor immune response. DCs-mediated cross presentation is subject to both intrinsic and extrinsic factors, including the homing and phenotype of DCs, the spatiotemporal trafficking and degradation kinetics of Ag, and multiple microenvironmental clues, with many details largely unexplored. Here, we systemically review the current mechanistic understanding and regulation strategies of cross presentation by heterogeneous DC populations. We also provide insights into the future exploitation of DCs cross presentation for a better clinical efficacy in antitumor therapy.

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