期刊
JOURNAL OF CONTROLLED RELEASE
卷 341, 期 -, 页码 184-205出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2021.11.011
关键词
Dendritic cells; Cross presentation; Regulation strategy; Clinical application; Anti-tumor therapy
资金
- National Nature Science Foundation of China [81573365, 81973296]
- National special fund for major drug development [2017ZX09201004015]
Dendritic cells play an important role in the cross presentation of exogenous antigens, contributing to a diversified T-cell activation and efficient anti-tumor immune response. Understanding the mechanisms and regulation strategies of cross presentation by DC populations can lead to better clinical efficacy in antitumor therapy.
The cross presentation of exogenous antigen (Ag) by dendritic cells (DCs) facilitates a diversified mode of T-cell activation, orchestrates specific humoral and cellular immunity, and contributes to an efficient anti-tumor immune response. DCs-mediated cross presentation is subject to both intrinsic and extrinsic factors, including the homing and phenotype of DCs, the spatiotemporal trafficking and degradation kinetics of Ag, and multiple microenvironmental clues, with many details largely unexplored. Here, we systemically review the current mechanistic understanding and regulation strategies of cross presentation by heterogeneous DC populations. We also provide insights into the future exploitation of DCs cross presentation for a better clinical efficacy in antitumor therapy.
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