Modeling and simulation of cell nuclear architecture reorganization process

We develop a special phase field/diffusive interface method to model the nuclear architecture reorganization process. In particular, we use a Lagrange multiplier approach in the phase field model to preserve the specific physical and geometrical constraints for the biological events. We develop several efficient and robust linear and weakly nonlinear schemes for this new model. To validate the model and numerical methods, we present ample numerical simulations which in particular reproduce several processes of nuclear architecture reorganization from the experiment literature. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

In this study, a special phase field/diffusive interface method was developed to model the nuclear architecture reorganization process, with a Lagrange multiplier approach used to preserve specific physical and geometrical constraints for biological events. Several efficient and robust linear and weakly nonlinear schemes were developed for this new model, with ample numerical simulations presented to validate the model and numerical methods, reproducing processes of nuclear architecture reorganization from experimental literature.