期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 608, 期 -, 页码 2278-2289出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.10.131
关键词
Burn wound healing; Antibacterial activity; Antibiofilm activity; GT/Ag cryogel; Hemostasis
资金
- National Natural Science Foundation of China [51973172]
- Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
- State Key Laboratory for Mechanical Behavior of Materials
- World-Class Universities (Disciplines)
- Characteristic Development Guidance Funds for the Central Universities
- Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2019LHM-KFKT008]
GT/Ag cryogels with outstanding antibacterial properties and effective absorption of wound exudates are excellent candidates for promoting burn wound repair.
Burn wounds are susceptible to bacterial infections and are usually accompanied by a large amount of exudate, making the treatment of burn wounds a challenge in the clinic. Here, we developed a biodegradable cryogel with high water absorption and good antibacterial and antibiofilm activity based on gelatin (GT) and silver nanoparticles (Ag NPs) to promote burn wound healing. The porous GT/Ag cryogel had a swelling ratio of up to 4000%, effectively absorbing wound exudate and allowing for gas exchange. Moreover, the GT/Ag cryogel had an excellent killing effect on methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA), which burn wounds are susceptible to, and can effectively remove mature biofilms. In the rat liver defect noncompressible hemorrhage model, GT/Ag cryogels with shape memory performance showed better hemostatic ability than commercial gelatin sponges. Most importantly, the GT/Ag cryogel was more effective than the Tegaderm (TM) dressing and GT cryogel in promoting wound contraction, collagen deposition, and angiogenesis and reducing inflammation in a PA-infected burn wound model. In addition, GT/Ag cryogels degraded in the body within 4 weeks, which alleviated the pain of peeling the dressing from the wound. Therefore, GT/Ag cryogels with outstanding antibacterial properties and effective absorption of wound exudates are excellent candidates for wound dressings to promote burn wound repair. (C) 2021 Elsevier Inc. All rights reserved.
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