期刊
JOURNAL OF CLUSTER SCIENCE
卷 34, 期 1, 页码 165-176出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-021-02205-2
关键词
Green synthesis; Almond gum; ZnO; Antibiofilm; Live and dead; Colon cancer
Nanomaterials, particularly metal oxide nanoparticles, are being considered as potential alternatives to traditional treatments in medicine. This study demonstrated a sustainable and simple synthesis of zinc oxide nanoparticles using almond gum Prunus dulcis as the capping agent. The synthesized nanoparticles showed significant antibacterial and antibiofilm activities against Staphylococcus aureus and Proteus vulgaris, as well as anti-colon cancer activity on a human colon cancer cell line.
Two of the main challenges in medicine are the fight against antibiotic resistance and cancer, and nowadays, nanomaterials are being postulated as potential alternatives to traditional treatments. Particularly, metal oxide nanoparticles could be an attractive option to replace conventional drugs, which generally present undesirable side effects. Besides, the green synthesis of the NPs provides several advantages, including less contamination. Hence, the present study described a sustainable and simple synthesis of zinc oxide NPs using almond gum Prunus dulcis (Alg-ZnONPs) as the capping agent. The Alg-ZnONPs showed significantly efficient antibacterial and antibiofilm activities against Staphylococcus aureus and Proteus vulgaris. The MIC values of Alg-ZnONPs were 3.25 mu g/ml against S. aureus and 2.12 mu g/ml against P. vulgaris, which confirm their significant antibacterial activity. Furthermore, the antibiofilm activity against both bacteria was evaluated, disclosing the inhibition of the biofilm growth at 100 mu g/ml. Additionally, in vitro anti-colon cancer activity of the Alg-ZnONPs was assessed on a human colon cancer cell line (HT-29), resulting in a significant reduction of the cell proliferation in 24 h, with an IC50 of 30.69 mu g/ml. The present work validates a straightforward and green synthesis of ZnONPs and unravels their potential for developing new antibiofilm agents and anti-colon cancer therapeutics.
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