Effects of e-health interventions on health outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis

Aims and Objectives To evaluate the effects of e-health interventions on disease activity, self-efficacy, pain and quality of life among patients with rheumatoid arthritis (RA). Background Prior systematic reviews have only reported the quality and features of e-health interventions in patients with RA. However, the effect of e-health interventions in patients with RA is unclear. Design Systematic review and meta-analysis. Methods This review was conducted following the PRISMA guideline. We searched 5 databases, including PubMed, EMBASE, CINAHL, Scopus and the Cochrane library. The risk of bias was assessed using the Cochrane risk of bias tool. The quality of the evidence was assessed via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. Using a random-effects model adopted the standardised mean difference (SMD) with a 95% confidence interval (CI). A chi-squared test and an I-2 test were used to assess heterogeneity. Subgroup analyses were conducted based on different controls. Results A total of 9 randomised control trials were included in this study. Compared with the control group, disease activity of the e-health group significantly decreased (SMD with 95% CI: -.17 [-.30, -.04], p = .01, I-2 = 1%). Meanwhile, trials with usual care control had a larger effect on disease activity (SMD with 95% CI: -.21 [-.40, -.02], p = .03, I-2 = 38%). The effect of e-health interventions on self-efficacy was controversial; pain and quality of life were negative in the currently included studies. The quality of evidence was rated as low for disease activity and very low for pain, self-efficacy and quality of life. Conclusions The effect of e-health interventions on disease activity was statistically significant. More well-designed randomised controlled trials are still needed to verify the effects in the future. Relevance to clinical practice This study shows the potential value of e-health in improving health outcomes in patients with RA.

Automated summary

This study evaluates the effects of e-health interventions on disease activity, self-efficacy, pain, and quality of life among patients with rheumatoid arthritis. The review includes 9 randomized control trials and finds that e-health interventions have a significant impact on disease activity, while the effects on self-efficacy, pain, and quality of life are still unclear.