期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 107, 期 6, 页码 1626-1635出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgac094
关键词
brown adipose tissue; cardiometabolic health; cold stimulus; circadian rhythm; gender differences; metabolism
资金
- Fundacion Alfonso Martin Escudero
- Dutch Heart Foundation [2017T016, CVON2014-02 ENERGISE, CVON2017 GENIUS-2]
- Dutch Society for Diabetes Research (NVDO)
- Dutch Diabetes Foundation [2015.81.1808]
- Netherlands Cardiovascular Research Initiative
Cold-induced thermogenesis is higher in the morning for males, while lipid metabolism is more modulated in the morning for females.
Context Cold exposure mobilizes lipids to feed thermogenic processes in organs, including brown adipose tissue (BAT). In rodents, BAT metabolic activity exhibits a diurnal rhythm, which is highest at the start of the wakeful period. Objective We investigated whether cold-induced thermogenesis displays diurnal variation in humans and differs between the sexes. Methods This randomized crossover study included 24 young and lean male (n = 12) and female (n = 12) participants who underwent 2.5-hour personalized cooling using water-perfused mattresses in the morning (7:45 am) and evening (7:45 pm), with 1 day in between. We measured energy expenditure (EE) and supraclavicular skin temperature in response to cold exposure. Results In males, cold-induced EE was higher in the morning than in the evening (+54% +/- 10% vs +30% +/- 7%; P = 0.05) but did not differ between morning and evening in females (+37% +/- 9% vs +30% +/- 10%; P = 0.42). Only in males, supraclavicular skin temperature upon cold increased more in morning than evening (+0.2 +/- 0.1 degrees C vs -0.2 +/- 0.2 degrees C; P = 0.05). In males, circulating free fatty acid (FFA) levels were increased after morning cold exposure, but not evening (+90% +/- 18% vs +9% +/- 8%; P < 0.001). In females, circulating FFA (+94% +/- 21% vs +20% +/- 5%; P = 0.006), but also triglycerides (+42% +/- 5% vs +29% +/- 4%, P = 0.01) and cholesterol levels (+17% +/- 2% vs 11% +/- 2%; P = 0.05) were more increased after cold exposure in morning than in evening. Conclusion Cold-induced thermogenesis is higher in morning than evening in males; however, lipid metabolism is more modulated in the morning than the evening in females.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据