4.7 Article

Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors

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Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E-Driven Papillary Thyroid Cancer Patients

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Summary: Routine genomic sequencing was used to identify additional oncogenic alterations in BRAF(v600E)-mutant papillary thyroid carcinoma (PTC) patients, which were associated with increased risk of recurrence, larger tumor size, and more advanced stage at presentation. Independent oncogenic mutations in the PI3K/AKT/mTOR pathway were also found to be significantly associated with disease-specific mortality (DSM), highlighting the importance of genomic profiling for prognosis and clinical strategy in PTC.

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