4.7 Article

Increased Prevalence of Fractures in Congenital Adrenal Hyperplasia: A Swedish Population-based National Cohort Study

期刊

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 107, 期 2, 页码 E475-E486

出版社

ENDOCRINE SOC
DOI: 10.1210/clinem/dgab712

关键词

21-hydroxylase deficiency; osteoporosis; trauma; bone mineral density; fall

资金

  1. Magnus Bergvall Foundation
  2. Karolinska Institutet
  3. Stockholm County Council
  4. Swedish Research Council [2017-02051]
  5. Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) [340-2013-5867]
  6. Swedish Research Council [2017-02051] Funding Source: Swedish Research Council

向作者/读者索取更多资源

Patients with congenital adrenal hyperplasia (CAH) have an increased prevalence of fractures, especially those associated with osteoporosis. This highlights the need for regular assessment of fracture risk and optimization of treatment.
Context: Low bone mineral density has been reported in individuals with congenital adrenal hyperplasia (CAH), but the prevalence of fractures is unclear. Objective: To study the prevalence of fractures in CAH. Design, Setting, and Participants: Patients with CAH (n = 714, all 21-hydroxylase deficiency) were compared with controls matched for sex and year and place of birth (n = 71 400). Data were derived by linking National Population-Based Registers. Main Outcome Measures: Number and type of fractures. Results: Mean age was 29.8 +/- 18.4 years. Individuals with CAH had more fractures compared to controls [23.5% vs 16.1%, odds ratio (OR) 1.61, 95% C11.35-1.91], and this was found in both sexes (females: 19.6% vs 13.3%, OR 1.57, 95% CI 1.23-2.02; males: 28.7% vs 19.6%, OR 1.65, 95% CI 1.29-2.12). Fractures were significantly increased in patients born before the introduction of neonatal screening but not in those born afterwards. Any major fracture associated with osteoporosis (spine, forearm, hip, or shoulder) was increased in all individuals with CAH (9.8% vs 7.5%, OR 1.34, 95% CI 1.05-1.72).The highest prevalence of fractures was seen in SV phenotype and I172N genotype while nonclassic phenotype and 12 splice genotype did not show increased prevalence. A transport accident as a car occupant and fall on the same level were more common in patients with CAH, both sexes, than in controls. Conclusions: Patients with CAH had an increased prevalence of both any fracture and fractures associated with osteoporosis (both sexes) but not for patients neonatally screened. We conclude that fracture risk assessment and glucocorticoid optimization should be performed regularly.

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