SARS-CoV-2 Vaccine-induced Thyroiditis: Safety of Revaccinations and Clinical Follow-up

Summary: The study compared low- and high-dose steroid regimens in the treatment of subacute thyroiditis (SAT), suggesting that low-dose steroid therapy may be sufficient to achieve complete recovery and better outcomes in SAT compared to high-dose therapy. The lower dose group had a lower recurrence rate and similar rates of hypothyroidism compared to the higher dose group.

ENDOCRINE PRACTICE (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Editorial Material Medicine, General & Internal

COVID-19 vaccination and a severe pain in the neck

Angelos Kyriacou et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

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Article Immunology

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination

Armando Patrizio et al.

Summary: This study reported a patient who developed autoimmune endocrine diseases (AIED) including Graves' disease and autoimmune diabetes mellitus after receiving the SARS-CoV-2 vaccine. Further studies are needed to better understand the underlying pathogenesis of AIED following SARS-CoV-2 vaccination.

JOURNAL OF AUTOIMMUNITY (2021)

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Editorial Material Ophthalmology

Thyroid Eye Disease Following COVID-19 Vaccine in a Patient With a History Graves' Disease: A Case Report

Tal J. Rubinstein

Summary: A 50-year-old woman developed symptoms of thyroid eye disease following her COVID-19 vaccination, likely associated with autoimmune/inflammatory syndrome. Clinicians should educate patients about the symptoms of thyroid eye disease post-vaccination.

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY (2021)

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Review Endocrinology & Metabolism

New aspects in the pathogenesis and management of subacute thyroiditis

Magdalena Stasiak et al.

Summary: Subacute thyroiditis (SAT) is a thyroid inflammatory disease, and recent years have seen significant new data on its epidemiology, pathogenesis, and management. Certain human leukocyte antigen (HLA) alleles have been shown to increase the risk of SAT, affecting its clinical course and recurrence risk.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2021)

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Article Endocrinology & Metabolism

Two Cases of Graves' Disease Following SARS-CoV-2 Vaccination: An Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Olga Vera-Lastra et al.

Summary: Two female health care workers developed clinical manifestations of thyroid hyperactivity, increased thyroid hormone levels, suppressed thyroid-stimulating hormone, and elevated antithyroid antibodies three days after receiving a SARS-CoV-2 vaccine. This indicates a potential link between SARS-CoV-2 vaccination and the onset of autoimmune thyroid diseases like Graves' disease.

THYROID (2021)

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Article Medicine, General & Internal

Subacute thyroiditis following COVID-19 vaccination

Pardis Soltanpoor et al.

Summary: Physicians should be vigilant about the potential development of subacute thyroiditis (SAT) following COVID-19 vaccination, as it may manifest with symptoms such as anterior neck pain, prolonged fever, or palpitations in recently vaccinated individuals, which should not be dismissed as common post-vaccination flu-like symptoms, thus enabling timely diagnosis and management.

CLINICAL CASE REPORTS (2021)

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Article Medicine, General & Internal

COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de Quervain's thyroiditis

Mohammad Sadiq Jeeyavudeen et al.

Summary: Subacute thyroiditis following vaccination is a rare presentation of thyrotoxicosis, which is usually self-limiting and should not discourage COVID-19 vaccination.

BMJ CASE REPORTS (2021)

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Article Medicine, General & Internal

Subacute thyroiditis after inactive SARS-CoV-2 vaccine

Emre Sedar Saygili et al.

Summary: Viral infections and vaccine administration have been linked to subacute thyroiditis. This case report highlights a rare occurrence of subacute thyroiditis following vaccination with CoronaVac.

BMJ CASE REPORTS (2021)

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Article Immunology

Autoimmune hepatitis triggered by SARS-CoV-2 vaccination

Elise Vuille-Lessard et al.

Summary: Autoimmune diseases have been reported to develop after SARS-CoV-2 infection, as well as following vaccination against the virus. The potential mechanisms involve molecular mimicry and bystander activation. Further investigation is needed to understand the link between SARS-CoV2 vaccination and autoimmune diseases.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology

Perspectives on vaccine induced thrombotic thrombocytopenia

Arad Dotan et al.

Summary: Recent reports have raised concerns about a vaccine-induced catastrophic thrombotic thrombocytopenia disorder associated with the ChAdOx1 nCoV-19 vaccine, leading to its suspension in multiple countries. It is hypothesized that a viral antigen in the vaccine triggered this rare adverse effect, although more research is needed.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Endocrinology & Metabolism

Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome

Burcin Gonul Iremli et al.

Summary: This study presents 3 cases of subacute thyroiditis after receiving the inactivated SARS-CoV-2 vaccine, describing the clinical, laboratory, and imaging features. The development of subacute thyroiditis occurred within a few days post-vaccination, with the possibility of being in the postpartum period facilitating the syndrome. This is the first report linking subacute thyroiditis to ASIA syndrome after COVID-19 vaccination.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Medicine, General & Internal

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

Alejandro Jara et al.

Summary: A study in Chile involving 10.2 million participants assessed the effectiveness of an inactivated SARS-CoV-2 vaccine developed in China. Fully immunized individuals had vaccine effectiveness of 65.9% for preventing Covid-19 and 87.5% for preventing hospitalization, 90.3% for preventing ICU admission, and 86.3% for preventing death.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Endocrinology & Metabolism

Letter to the Editor: Thyroiditis and Thyrotoxicosis After the SARS-CoV-2 mRNA Vaccine

Jonathan Schimmel et al.

THYROID (2021)

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Article Biotechnology & Applied Microbiology

Subacute thyroiditis following COVID-19 vaccination in a 67-year-old male patient: a case report

Melisa Sahin Tekin et al.

Summary: Subacute thyroiditis is the most common cause of painful thyroid gland diseases, characterized by inflammation of the thyroid gland and often occurring after viral upper respiratory tract infections. COVID-19 and vaccines are also associated with cases of subacute thyroiditis.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Medicine, General & Internal

Case Report: Two Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccination

Catherine Bornemann et al.

Summary: The article reports two cases of subacute thyroiditis following SARS-CoV-2 vaccination, both presenting symptoms 2 weeks after vaccination with anterior and lateral neck pain. Clinical test results and cytological findings were consistent with subacute thyroiditis.

FRONTIERS IN MEDICINE (2021)

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Letter Endocrinology & Metabolism

Thyrotoxicosis after COVID-19 vaccination: seven case reports and a literature review

Kyung Ae Lee et al.

ENDOCRINE (2021)

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Letter Endocrinology & Metabolism

Aggravation of hyperthyroidism after heterologous prime-boost immunization with inactivated and adenovirus-vectored SAdRS-CoV-2 vaccine in a patient with Graves' disease

Chutintorn Sriphrapradang

ENDOCRINE (2021)

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Article Endocrinology & Metabolism

Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome

Burcin Gonul Iremli et al.

Summary: This study reports three cases of subacute thyroiditis related to the COVID-19 vaccine, which may develop within a few days post-vaccination. Being in the postpartum period may facilitate the development of ASIA syndrome after COVID-19 vaccination. Clinicians should be aware of the possibility of subacute thyroiditis as a manifestation of ASIA syndrome following COVID-19 vaccination.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Letter Immunology