Thermochemistry of solution of methylpheophorbide a, dioxidine and their conjugate in chloroform from 298.15 K to 318.15 K

This paper focuses on the study of thermochemistry of solution and transfer of potential hydrophobic photosensitizers, viz. 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-3-{(O-methylcarbamoyl)ethyl}-4,8,13,1 8-tetramethyl-20-oxo-phorbine (Methylpheophorbide a, comp. 1), [3-(hydroxymethyl)-1-oxido-4-oxo quinoxalin-4-ium-2-yl]methanol (Dioxidine, comp. 2) and their conjugate 9-ethenyl-14-ethyl-3-{[2-(3-hydroxymethyl)]-1-oxido-4-oxoquinoxalin-4-ium-2-methyleneoxy}carbamoyl}ethyl)-4,8,13,18-tetrame thyl-20-oxo-phorbine (Conjugate, comp. 3), in liquid chloroform (CHCl3) and N,N-dimethylformamide (DMF) between the temperatures of 298.15 K and 318.15 K. The standard enthalpies and heat capacities of solution as well as partial molar heat capacities of these species and some non-electrolytes modeling their side-chains have been computed from experimental enthalpies of solution and compared with previously reported quantities to highlight several important features of solvation of potential drugs in H-donor and H-acceptor media. (C) 2021 Elsevier Ltd.

Automated summary

This study focuses on the thermochemistry and transfer of potential hydrophobic photosensitizers in different solvents, comparing their properties at different temperatures. The standard enthalpies, heat capacities, and partial molar heat capacities of these species were calculated from experimental data and compared with previous studies, highlighting the solvation characteristics of potential drugs in H-donor and H-acceptor media.