TRPV1 Activation by Anandamide via a Unique Lipid Pathway

The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.

Automated summary

This study reveals that the endocannabinoid anandamide can activate the TRPV1 channel at a unique peripheral binding site, expanding the knowledge of TRPV1 and aiding in the development of new TRPV1 modulators.