期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 42, 期 4, 页码 572-583出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X211060741
关键词
Cerebrospinal fluid volume; cerebrospinal fluid flow; diffusion MRI; subacute stage; ischemic stroke
资金
- National Research Foundation of Korea grants from the Korean government [2018R1A6A1A03025810, 2018M3C7 A1056887]
- Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C1135]
- 2021 Joint Research Project of Institutes of Science and Technology
This study quantitatively measured CSF flow and volume using MRI and observed the changes in CSF dynamics through Monte Carlo simulations. Longitudinal monitoring showed a strong positive correlation between CSF peak velocity and diffusion signals, and a positive correlation between ventricular CSF volume and D* in lateral and ventral-third ventricles.
Quantitative measurement of cerebrospinal fluid (CSF) flow and volume and longitudinal monitoring of CSF dynamics provide insights into the compensatory characteristics of post-stroke CSF. In this study, we compared the MRI pseudo-diffusion index (D*) of live and sacrificed rat brains to confirm the effect of ventricular CSF flow on diffusion signals. We observed the relationship between the CSF peak velocities and D* through Monte Carlo (MC) simulations to further understand the source of D* contrast. We also determined the dominant CSF flow using D* in three directions. Finally, we investigated the dynamic evolutions of ventricular CSF flow and volume in a stroke rat model (n = 8) from preoperative to up to 45 days after surgery and determined the correlation between ventricular CSF volume and flow. MC simulations showed a strong positive correlation between the CSF peak velocity and D* (r = 0.99). The dominant CSF flow variations in the 3D ventricle could be measured using the maximum D* map. A longitudinal positive correlation between ventricular CSF volume and D* was observed in the lateral (r = 0.74) and ventral-third (r = 0.81) ventricles, respectively. The directional D* measurements provide quantitative CSF volume and flow information, which would provide useful insights into ischemic stroke with diffusion MRI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据