期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 42, 期 5, 页码 891-900出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X211065199
关键词
Cerebral oxygenation; hypoxic-ischemic injury; magnetic resonance spectroscopy; neonatal; quantitative susceptibility mapping
资金
- Loma Linda University Medical Center Department of Radiology
QSM-derived venous susceptibility is sensitive to cerebral oxygenation status across various oxygenation states and strongly correlated with brain tissue O2 tension, while showing no correlation with CBF.
Prominence of cerebral veins using susceptibility weighted magnetic resonance imaging (SWI) has been used as a qualitative indicator of cerebral venous oxygenation (CvO(2)). Quantitative susceptibility mapping (QSM) adds more precision to the assessment of CvO(2), but has not been applied to neonatal hypoxic ischemic injury (HII). We proposed to study QSM measures of venous susceptibility and their correlation with direct measures of brain oxygenation and cerebral blood flow (CBF) in the neonatal piglet. The association of QSM intravascular cerebral venous susceptibility, with brain tissue O-2 tension, CBF, cortical tissue oxyhemoglobin saturation, and the partial pressure of oxygen in arterial blood measurement during various oxygenation states was determined by linear regression. Compared to normoxia, venous susceptibility in the straight sinus increased 56.8 +/- 25.4% during hypoxia, while decreasing during hyperoxia (23.5 +/- 32.9%) and hypercapnia (23.3 +/- 73.1%), which was highly correlated to all other measures of oxygenation (p < 0.0001) but did not correlate to CBF (p = 0.82). These findings demonstrate a strong relationship between venous susceptibility and brain tissue O-2 tension. Our results suggest that QSM-derived venous susceptibility is sensitive to cerebral oxygenation status across various oxygenation states.
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