期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 237, 期 2, 页码 1171-1181出版社
WILEY
DOI: 10.1002/jcp.30616
关键词
caveolae; mechanotransduction; meniscus; meniscus fibrochondrocytes; signal transduction
资金
- Faculty of Graduate Studies and Research University of Alberta: Alberta Graduate Excellence Scholarship
- Canada Foundation for Innovation [CFI 33786]
- Institute of Musculoskeletal Health and Arthritis [CIHR MOP 125921]
- University Hospital of Alberta Foundation (UHF) [RES0028185, RES0045921]
- Alberta Cancer Foundation: Mickleborough Interfacial Biosciences Research Program
- Natural Sciences and Engineering Research Council of Canada: Alexander Graham Bell ScholarshipMasters Prog [NSERC RGPIN-2018-06290]
MFCs play a crucial role in regulating the biomechanical properties of the knee meniscus, and understanding their mechanotransductive mechanism is essential for advancing research in this field.
Meniscus fibrochondrocytes (MFCs) are an important cell population responsible for regulating the biomechanical properties of the knee meniscus. Despite their significance, not much is known about them, including how they sense and respond to mechanical stimuli. Due to the mechanical nature of the knee joint, it is therefore paramount to our understanding of the meniscus that its mechanotransductive mechanism be elucidated. In this review, we will summarize the current knowledge on mechanotransduction in MFCs and highlight the relevance of caveolae in lieu of a recent discovery. Additionally, we will discuss the importance of future studies in this area to help advance the field of meniscus research.
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