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Review
Biotechnology & Applied Microbiology
Saeedreza Zeibi Shirejini et al.
Summary: This article summarizes the conventional and microfluidic-based methods for exosome isolation, highlighting their strengths and limitations. Microfluidic devices, in particular, offer a promising approach to efficiently isolate exosomes, providing unprecedented tools for molecular biology and clinical applications in exosome research.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Urology & Nephrology
Yasuyoshi Miyata et al.
Summary: This study found that intravesical therapy with MMC and Ara-C is effective in increasing urinary pH and improving RFS in patients with intermediate-risk NMIBC. Additionally, the higher urinary pH level associated with Ara-C therapy was speculated to contribute to increased anti-cancer effects.
Review
Genetics & Heredity
Ryan L. Kan et al.
Summary: Epigenetic modifications play a crucial role in gene expression regulation through modifications on genomic DNA, histones, and more recently, mRNA. These modifications, especially the common N6-methyladenosine (m6A) methylation, not only influence RNA stability and translation efficiency, but also interact with histone/DNA epigenetic mechanisms to specify transcriptional outputs and recruit chromatin modifiers. This review focuses on dissecting the feedback circuits orchestrated by m6A, which regulate histone modifications and the activity of regulatory RNAs, such as long noncoding RNA and chromosome-associated regulatory RNA. The evidence suggests that m6A acts as a versatile checkpoint linking different layers of gene regulation.
TRENDS IN GENETICS
(2022)
Review
Engineering, Biomedical
Shaobo Ruan et al.
Summary: Cancer immunotherapy has shown benefits in recent years, but novel targeting approaches and modulators are needed for broader patient populations. Extracellular vesicles (EVs) offer targeted immunity modulation and improved efficacy, with unique properties like surface markers and immunomodulatory functions. Future potential lies in EVs as a cancer immunotherapeutic biomaterial through reprogramming strategies and addressing unique challenges.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Cell Biology
Vittoria Graziani et al.
Summary: This review focuses on the role of amoeboid behavior in cancer cell invasion and metastasis, as well as the molecular biomarkers and physicochemical triggers associated with it. The authors suggest that targeting these characteristics could lead to therapeutic opportunities for cancer treatment.
TRENDS IN CELL BIOLOGY
(2022)
Review
Urology & Nephrology
J. Alfred Witjes et al.
Summary: This article presents the updated European Association of Urology guidelines for muscle-invasive and metastatic bladder cancer, providing practical evidence-based recommendations and consensus statements on clinical management. The guidelines cover a broad scope and incorporate the latest research findings and results from consensus meetings.
Review
Biochemistry & Molecular Biology
Fernanda G. Kugeratski et al.
Summary: Exosomes play crucial roles in cancer by either promoting tumor development or inhibiting tumor immune suppression. They deliver signals that affect immune regulation of lymphoid and myeloid cell populations in tumors.
Review
Biochemistry & Molecular Biology
Bikash Chandra Jena et al.
Summary: The tumor microenvironment (TME) is a complex network of cellular organization supporting tumor growth through intercellular communication, with a pivotal role in the development of anti-cancer drug resistance. Exosomes have emerged as key players in mediating bidirectional interplay between tumor and TME, promoting drug resistance and challenging therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemistry & Molecular Biology
Yu-Shui Ma et al.
Summary: Exosomes, derived from the nuclear endosome and plasma membrane, are effective carriers of intercellular signals, efficiently transferring proteins, lipids, and nucleic acids between cells. They have stable biological characteristics, diverse contents, non-invasive signaling molecule introduction pathways, and rapid detection capabilities, making them promising clinical diagnostic markers for various pathological conditions.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Qitai Zhao et al.
Summary: This study identified the correlation between monocytic myeloid-derived suppressor cells (M-MDSCs) and cisplatin resistance in patients with esophageal squamous cell carcinoma (ESCC). Furthermore, it was found that cancer-associated fibroblasts (CAFs) promoted the differentiation of monocytes into M-MDSCs through the secretion of interleukin-6 (IL-6) and exosome-packed microRNA-21 (miR-21), activating the STAT3 signaling pathway. The study highlights the potential of targeting the STAT3 signaling pathway as a strategy to reverse drug resistance in ESCC patients with high infiltration of CAFs and myeloid cells.
Article
Cell Biology
Wenjuan Di et al.
Summary: The study revealed that miR-146b-5p derived from exosomes released by colorectal cancer cells could induce browning of white adipose tissues and accelerate lipolysis, playing a crucial role in improving the condition of cancer cachexia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Candice de Boer et al.
Summary: This study aimed to develop a multi-step purification protocol to isolate serum exosomes and evaluate their regenerative potential. The purification process of UC DG SEC significantly improved the removal of lipoproteins from serum exosomes, leading to enhanced cellular proliferation and potential angiogenic response in vivo. The purified exosomes showed increased levels of exosome-related proteins and reduced amounts of lipoproteins, indicating a more accurate identification of serum exosome functional activity and composition.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Luana Greco et al.
Summary: Cancer metastasis involves multiple steps, including local invasion, intravasation, colonization at distant sites, and outgrowth of lesions. Epithelial to mesenchymal transition (EMT) enables cancer cells to overcome barriers and have plasticity during transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Multidisciplinary Sciences
Nicol Parada et al.
Summary: Exosomes have a short circulation half-life due to macrophage-mediated phagocytosis, hindering their therapeutic effect. Surface modification to generate 'invisible' exosomes can inhibit clearance and increase targeted delivery efficiency.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Oncology
Maryam Hashemipour et al.
Summary: miRNAs and lncRNAs play essential biological roles through various mechanisms, regulating gene expression and driving pathways in gynecological cancers. Exosomes serve as natural carriers of non-coding RNAs, focusing research on exosomal microRNAs and long non-coding RNAs for potential therapeutic applications.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pooja Jain et al.
Summary: Bladder cancer is the 10th most common malignancy worldwide with a 5-year survival rate of 75%, but 70% of the cases develop chemoresistance and progress to the muscle invasive stage. Nanotechnology has shown promise in targeted drug delivery to bladder cancer cells, offering potential for better treatment management.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Cell Biology
Fatemeh Mirzadeh Azad et al.
Summary: Long noncoding RNAs play a crucial role in stem cell maintenance and differentiation, exhibiting diverse functions through interactions with proteins, DNA, and RNA. This heterogeneity in function enhances the capabilities of the lncRNome toolkit but also poses challenges in predicting the functions of novel lncRNAs.
TRENDS IN CELL BIOLOGY
(2021)
Review
Immunology
Jianxuan Wu et al.
Summary: T lymphocytes play important roles in bladder diseases, potentially affecting the host by influencing the clearance of bacteria or cancer cells and modulating autoinflammation. Recent research suggests that bladder T cell functions may be influenced by interactions with the bladder microbiota and other immunostimulants.
TRENDS IN IMMUNOLOGY
(2021)
Review
Oncology
Andres Rincon-Riveros et al.
Summary: Extracellular vesicles, such as exosomes, have the potential to serve as biomarkers for cancer development, impacting various aspects of tumor progression and immune regulation.
Review
Oncology
Tiziana Feola et al.
Summary: NECs are heterogeneous tumors that can be further divided into two prognostically distinct categories based on the Ki67 LI < 55%. Those with lower Ki67 LI have a better prognosis and should be treated and monitored differently from those with higher Ki67 LI.
Article
Medicine, General & Internal
Hao Lin et al.
Summary: This study analyzed the clinical significance of dynamic monitoring of liver function in patients with COVID-19. The results showed that changes in liver function indicators are not obvious in the early stage of COVID-19, but clinically significant changes might be observed in severe cases.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Biochemistry & Molecular Biology
Guangyue Luo et al.
Summary: Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating the miR-34b-5p/ABCB1 axis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Review
Cell Biology
Yoko Katsuno et al.
Summary: Epithelial cells suppress epithelial characteristics and exhibit mesenchymal traits to migrate and adapt, regulated by cooperation of various signaling pathways. TGF-beta and related proteins play key roles in directing epithelial plasticity, impacting metazoan development, wound healing, fibrosis, and cancer progression.
DEVELOPMENTAL CELL
(2021)
Review
Oncology
Yi Yi et al.
Summary: Breast cancer is the most common malignancy among women worldwide, and exosomal non-coding RNAs play significant regulatory roles in breast cancer cells, affecting angiogenesis, immunoregulation, proliferation, and migration.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Jing Li et al.
Summary: Exosomes play critical roles in promoting chemoresistance in cancer through various mechanisms. Due to their stability, specificity, and sensitivity, exosomes can serve as biomarkers in liquid biopsies to monitor the current status and progression of cancer chemoresistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hao Zhang et al.
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cardiocerebrovascular diseases by regulating gene expression and influencing disease progression. Studies have shown that abnormal expression of lncRNAs is closely related to the occurrence and progression of these diseases, making them potential biomarkers for diagnosis and prognosis.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Immunology
Shawna Benjamin-Davalos et al.
Summary: Exosomes play a vital role in intercellular communication and their immunomodulatory potential is a focus in cancer research. However, technical challenges arise during exosome isolation and the co-elution of exosomes with soluble factors makes it difficult to ascertain their specific contribution to immunosuppression in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kunfeng Bai et al.
Summary: Exosomes, a subset of extracellular vesicles, play important roles in reproduction processes, especially during pregnancy. Placenta-derived exosomes (pEXO) in maternal blood could be potential biomarkers for pregnancy-related diseases. Furthermore, pEXO are key in establishing maternal immune tolerance during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yanguo Xin et al.
Summary: Cell proliferation is an essential cellular process for tissue maintenance and remodeling. Mitofusin-2 (Mfn-2) plays a crucial role in regulating cell proliferation by maintaining mitochondrial network and bioenergetics, making it a potential therapeutic target for pathological cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Na-Kyeong Lee et al.
Summary: Cancer stem cells (CSCs) play crucial roles in tumor initiation, metastasis, and therapy resistance, while exosomes derived from CSCs (CSCEXs) have become a recent focus of research for their roles in transmitting information and influencing cancer progression. Understanding the functions of CSCEXs is essential for developing effective therapeutic strategies for cancer treatment.
Review
Pharmacology & Pharmacy
Peiwen Fu et al.
Summary: Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging, possessing unique physicochemical properties, biological features, and mechanical aspects. This review analyzes the pros and cons of EVs as a delivery platform, elaborates on rational design improvements, and compares pharmaceutical loading approaches, aiming to construct a clinically available and effective nano-/micro-carrier.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Weina Ke et al.
Summary: Exosomes, as endogenous nanocarriers, show great promise in meeting the needs of nucleic acid nanoparticles in diagnostics and therapeutics. Their lipid membranes can carry different types of drugs and nucleic acids simultaneously and be surface modified, expanding their diverse biomedical applications.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pathology
Sukanya Roy et al.
Summary: Increased lymphangiogenesis and lymph node metastasis are important prognostic indicators in aggressive hepatobiliary malignancies. This review provides a detailed perspective on alterations in the hepatic lymphatic system during liver malignancies, as well as potential molecular signaling mechanisms and growth factors for future therapeutic targets. Targeting tumor-associated lymphangiogenesis presents current challenges and opportunities for effective therapeutic interventions.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Chemistry, Analytical
Sisi Huang et al.
Summary: Exosomes, membrane-bound vesicles secreted by cells, are proposed as measurable indicators of disease in blood plasma. Current methods for isolating exosomes from plasma are complex and costly, often resulting in co-extraction of lipoproteins. A new rapid hydrophobic interaction chromatography method shows promise in efficiently purifying exosomes while excluding LDLs.
ANALYTICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Monu Pandey et al.
Summary: SCLC, a smoking-related aggressive cancer, shows universal loss of TP53 and RB1 tumor suppressor genes, with miRNAs playing a key role in regulating cell processes and potential clinical applications in monitoring chemotherapy responses and predicting survival outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Engineering, Biomedical
Lili Cheng et al.
Summary: The designed hybrid therapeutic nanovesicles, hGLV, based on CD47 immune checkpoint blockade demonstrated long blood circulation, improved macrophage-mediated phagocytosis of tumor cells by blocking CD47 signal, targeted homologous tumors in mice effectively for preferential accumulation at tumor sites. Furthermore, hGLV loaded with photothermal agent achieved excellent photothermal therapy (PTT) in eliminating tumors, inducing immunogenic cell death, generating tumor-associated antigens, and promoting immune responses with the help of co-encapsulated immune adjuvant. Such hybrid nanovesicles show promise in drug delivery for cancer treatment.
Editorial Material
Urology & Nephrology
Adi Kartolo et al.
Review
Biochemistry & Molecular Biology
Paulina Wigner et al.
Summary: Bladder cancer is the second most common genitourinary cancer, with high recurrence risk. Natural substances such as curcumin and sulforaphane may play an important role in the treatment of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rahul Mittal et al.
Summary: Exosomes are small extracellular membrane particles that have the potential to be used as biomarkers and drug delivery systems, especially in the neurological system and inner ear. Research suggests that exosomes can be utilized as biomarkers in diseased states and for drug delivery to hard-to-reach organs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Han et al.
Summary: The study reveals that exosomal CCAT1 derived from PANC-1 cells enhances angiogenesis of HUVECs by regulating the miR-138-5p/HMGA1 axis.
Article
Endocrinology & Metabolism
Jingfang Chen et al.
Summary: Exosomes are important for intercellular communication and play a role in regulating biological function through the transport of various cargos. Diabetic nephropathy is a serious complication with no current effective treatment, and exosomes may offer new biomarkers and therapeutic targets for this condition.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Neurosciences
Samantha L. Reed et al.
Summary: Extracellular vesicles (EVs) are cell-derived membranous particles that contain various molecules and play important roles in intercellular communication. They have shown efficacy in models of neurological disorders by reducing symptoms and providing benefits, making them a promising avenue for future research and clinical applications.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Cell Biology
Yang Tian et al.
Summary: Exosomes, secreted by mammalian cells, play a role in cell-to-cell transportation and are involved in various diseases, including neurodegenerative diseases. In the central nervous system, exosomes from neurons or glia cells have unique effects on CNS-related diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Ninggang Yang et al.
Summary: This study demonstrated that grape seed proanthocyanidins effectively inhibit the migration and invasion of bladder cancer cells by reversing epithelial-mesenchymal transition through suppression of the TGF-beta signaling pathway, suggesting their potential as chemopreventive and therapeutic agents against bladder cancer.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Xu Yang et al.
Summary: This study demonstrates that elevated expression of LINC00909 in tumor and serum specimens of ovarian cancer patients may serve as a promising biomarker for diagnosis, with potential correlation to disease progression and prognosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Jun Lu et al.
Summary: Osteoporosis is an aging-related disease characterized by permanent bone tissue atrophy, with most patients exhibiting high levels of oxidative stress. Exosomes play a role in delivering miRNAs for intercellular communication in OP, modulating physiological processes including the response to oxidative stress. Research delves into the interaction between exosomal miRNAs and oxidative stress in OP, with a focus on the potential advantages of exo-based miRNA delivery in treatment strategies.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Chemistry, Multidisciplinary
Shayna Sharma et al.
Summary: EVs can serve as natural carriers for drug delivery, and their fusion with engineered nanostructures has been proposed to enhance drug loading and achieve site-specific delivery. Challenges such as isolation, heterogeneity, coexistence with biomolecules, and lack of targeted delivery have limited the potential of EVs.
Review
Chemistry, Multidisciplinary
Huiwen Xiong et al.
Summary: Exosomes, nano-sized vesicles secreted by cells, have great potential as biomarkers in early cancer diagnosis and treatment evaluation. Researchers have published numerous papers on various detection methods to improve sensitivity and reproducibility, and are also exploring the molecular composition of exosomes and the application of machine learning methods in exosome research.
Review
Immunology
Giuseppina Emanuela Grieco et al.
Summary: EVs are generated by cells through complex molecular mechanisms and contain molecular cargo such as ncRNA, mRNA, and proteins that modulate biological processes and are altered in diseases including autoimmune diseases. EVs have a promising role as biomarkers in disease progression, with studies showing specific cargo alterations in autoimmune diseases like T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Khalil Khalaf et al.
Summary: The tumor microenvironment (TME) is a complex and dynamic tissue containing various components such as blood supply, immune cells, and extracellular matrix, which together create an environment conducive to tumor cell growth and proliferation. Cellular crosstalk, cell-to-ECM communication, exosomes, and specific metabolic patterns play crucial roles in immune evasion and therapy resistance in the TME. In addition, characteristics like hypoxia, metabolic abnormalities, and mechanical forces further contribute to treatment resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Yi Yao et al.
Summary: Dendritic cells (DCs)-based cancer vaccines have not been very successful due to tumor-mediated immunosuppression, leading to limited clinical efficacy. DC-derived exosomes (DCexos) are considered as a promising alternative to DC-based vaccines, as they are more resistant to tumor-mediated suppression and have shown better anti-tumor efficacy in pre-clinical models.
Review
Oncology
America Campos et al.
Summary: The article discusses the association between miRNAs within extracellular vesicles (EVs) and chemotherapy resistance, identifying certain miRNAs in various cancers linked to chemoresistance. Studies suggest that miR-21, miR-222, and miR-155 have roles in response to chemotherapy in different types of tumors.
Review
Oncology
Jian Yi Chai et al.
Summary: The Hedgehog (Hh) signaling pathway plays a crucial role in cancer treatment, particularly in chemotherapy resistance. Understanding the mechanisms regulated by Hh signaling is essential for developing more effective treatment strategies in cancer therapy.
Review
Oncology
Renato Burgos-Ravanal et al.
Summary: EVs play a crucial role in cancer by facilitating cell communication, promoting the acquisition of specific traits by cancer cells, participating in the development of drug resistance, and being proposed for therapeutic and prognostic purposes.
Article
Oncology
Peiyu Wang et al.
Summary: The study found that plasma-activated medium (PAM) is more effective at inhibiting cancer cells with epithelial-mesenchymal transition (EMT), which are often resistant to other therapies. This suggests a potential novel treatment option for aggressive cancers exhibiting EMT, highlighting the promising role of cold atmospheric plasma (CAP) and PAM in onco-therapy.
Review
Oncology
Md. Hafiz Uddin et al.
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Oncology
Maria Eldh et al.
Summary: The study investigated the release of exosomes from urinary bladder tissue post-TUR-B in UBC patients to find cancer-promoting exosomes originating from both tumour-proximal and tumour-distant sites, highlighting the need for early radical cystectomy. This suggests that the entire bladder tissue may release exosomes contributing to metastasis despite the absence of detectable tumour, supporting the role of exosomes as potential biomarkers and mediators of metastatic spread. Additionally, the enrichment of cancer-related pathways in tissue-derived exosomes from both sites strengthens the hypothesis and emphasizes the necessity for early removal of the bladder in UBC patients.
Review
Oncology
Linlin Wang et al.
Summary: Studies have shown that various cells in the tumor microenvironment release extracellular vesicles (EVs) encapsulating different molecules, which can be taken up by lymph endothelial cells (LECs) to regulate tumor lymphangiogenesis. EVs may serve as biomarkers for tumor lymph node metastasis and hold potential for anti-tumor lymphangiogenesis therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Soudeh Ghafouri-Fard et al.
Summary: Extracellular vesicles play important roles in cell-cell communication, inflammation modulation, cell proliferation, and tissue regeneration, with advantages such as lower risk and easier production and storage compared to cell therapy. Particularly, exosomes derived from mesenchymal stem cells are introduced as a therapeutic option for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yuxuan Zhong et al.
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jia Feng et al.
Summary: Exosomes, as intracellular mediators, have been implicated in the pathophysiological processes of various diseases, including spinal cord injury. They are considered to potentially play a significant role in the treatment of SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Erkang Yi et al.
Summary: IL6-AS1 is upregulated in chronic obstructive pulmonary disease and promotes inflammation by enhancing the expression of inflammatory factors. It acts as an endogenous sponge in the cytoplasm to stabilize IL-6 mRNA, and in the nucleus, it recruits early B-cell factor 1 to promote IL-6 transcription.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Hanhao Zheng et al.
Summary: In patients with lymph node metastatic bladder cancer, lncRNA BCYRN1 was found to be significantly upregulated in urinary exosomes and associated with BCa LN metastasis. BCYRN1 enhances lymphatic metastasis of BCa by activating Wnt/β-catenin signaling and promoting VEGF-C secretion. Blocking VEGFR3 can impair BCYRN1-induced LN metastasis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Xiaoyun He et al.
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemical Research Methods
Shibo Cheng et al.
Summary: Extracellular vesicles, including exosomes, play a significant role in cancer diagnosis and therapeutic monitoring by carrying a selective set of biomolecules from tumor cells. Microfluidics offers a disruptive platform for EV isolation and analysis due to its advantages in promoting the development of new molecular and cellular sensing systems with improved sensitivity and specificity. Despite current challenges in EV research, adapting microfluidic techniques shows promise in assessing emerging EV-associated biomarkers for clinical applications.
Review
Medicine, Research & Experimental
Yu-Yan Xiong et al.
Summary: AMI is a leading cause of mortality globally, with inflammatory response playing a pivotal role in myocardial necrosis and ventricular remodeling. Exosomes, containing biologically active substances, have emerged as key players in immune regulation post AMI, alongside a variety of immune cells working together for tissue cleanup and repair. Research into exosomes from both endogenous immune cells and exogenous stem cells has shown promising therapeutic effects in immunomodulation for myocardial repair post AMI.
Article
Medicine, Research & Experimental
Changhao Chen et al.
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Biotechnology & Applied Microbiology
Peiming Zheng et al.
ONCOTARGETS AND THERAPY
(2020)
Article
Biochemical Research Methods
Sheng Guan et al.
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Cell Biology
Zhicheng Yao et al.
Review
Pharmacology & Pharmacy
Qingsong Hu et al.
PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Surgery
Xin Guo et al.
Review
Oncology
Cinzia Giordano et al.
Article
Cell Biology
Cheng-Shuo Huang et al.
Review
Biochemistry & Molecular Biology
Chun-Jie Guo et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Christian Schulte et al.
TRENDS IN MOLECULAR MEDICINE
(2020)
Review
Oncology
Khairunnisa' Md Yusof et al.
Article
Oncology
Xiao Yu et al.
Review
Oncology
Wei Yan et al.
Review
Pharmacology & Pharmacy
Yong Zhang et al.
PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Urology & Nephrology
Varune Rohan Ramnarine et al.
Article
Cell Biology
Erik R. Abels et al.
Article
Biochemical Research Methods
Feng Cao et al.
Article
Biotechnology & Applied Microbiology
Chenchen Cai et al.
ONCOTARGETS AND THERAPY
(2019)
Review
Oncology
Qi Li et al.
Article
Oncology
Xiaofan Guo et al.
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Cell Biology
Shujun Zhang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Mengjie Zhao et al.
Review
Genetics & Heredity
Hyunmin Lee et al.
TRENDS IN GENETICS
(2019)
Article
Biochemical Research Methods
Mingrui An et al.
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Medicine, Research & Experimental
Jiansong Wang et al.
MEDICAL SCIENCE MONITOR
(2018)
Review
Medicine, Research & Experimental
Theresa L. Whiteside
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Multidisciplinary Sciences
Claudia Berrondo et al.
